Warm gas during keyhole surgery may cut pain and opioid use

NCT ID NCT05934981

Completed Symptom relief Sponsor: Bordeaux Colorectal Institute Academy Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using warm, humidified carbon dioxide gas during low-pressure laparoscopic colorectal surgery reduces pain 24 hours after the procedure. 148 adults having surgery for colon or rectal tumors (benign or malignant) took part. One group received warm, moist gas; the other received standard cold, dry gas. The main goal was to see how many patients had mild pain (score 3 or less on a 0–10 scale) without needing strong painkillers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: warm, humidified carbon dioxide gas used during laparoscopic surgery
What this could lead to: If it works, this could lead to less pain and fewer opioids after colorectal surgery, helping patients recover more comfortably.
What could go wrong: This is a small, completed trial with 148 patients. The benefit may be small or not apply to all surgeries. Pain is subjective and results may not be widely generalizable.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BENIGN OR MALIGNANT RECTAL OR COLON TUMORS COLORECTAL SURGERY

Contacts and locations

Locations

Clinique TIVOLI DUCOS - Bordeaux Colorectal Institute

Bordeaux, France
HOPITAL NORD APHM - Service de Chirurgie Digestive

Marseille, France

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