Could a Low-Dose opioid blocker ease diabetic nerve pain without the risks?
NCT ID NCT04678895
First seen May 12, 2026 · Last updated Jun 23, 2026 · Updated 4 times
Summary
This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy. About 35 adults with long-term diabetic nerve pain who haven't found relief from standard treatments will receive either LDN or a placebo. The goal is to see if LDN can be a non-opioid alternative to improve pain and daily function.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PAINFUL DIABETIC NEUROPATHY are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03766, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Low-dose naltrexone (LDN)
What this could lead to
If it works, this could offer a safe, non-opioid pain relief option for people with diabetic nerve pain.
What could go wrong
This is a small, early-phase trial with only 35 participants. It may not show clear benefit, and results may not apply to everyone with diabetic neuropathy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.