Could a tiny dose of LSD help adults with ADHD?

NCT ID NCT05200936

Completed Disease control Sponsor: Definium Therapeutics US, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether repeated low doses of LSD (called MM120) can safely help adults with ADHD. Fifty-three adults took either the drug or a placebo, and researchers measured changes in ADHD symptoms using a standard rating scale. The goal was to see if this approach could be a new way to manage ADHD without needing daily medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LSD (lysergic acid diethylamide) as a low-dose tartrate salt (MM120)
What this could lead to: If it works, this could point toward a new, non-daily medication option for managing ADHD symptoms in adults.
What could go wrong: This is a small, early-phase proof-of-concept trial with only 53 participants. The psychedelic effects of LSD may cause hallucinations or other side effects, and it is not yet proven effective or safe for ADHD.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHD ATTENTION DEFICIT DISORDER

Contacts and locations

Locations

Maastricht University

Maastricht, Netherlands
University Hospital Basel

Basel, Switzerland

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