Could a simple immune boost stop recurrent miscarriages?

NCT ID NCT03970954

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 37 times

Summary

This early-phase study tested whether low doses of a protein called interleukin-2 (IL-2) could increase regulatory T cells—immune cells that help the body accept a pregnancy—in 18 women who had at least five unexplained early miscarriages. The goal was to see if this approach could prevent the immune system from rejecting the fetus. The study measured changes in blood Treg levels but did not directly assess pregnancy outcomes, so more research is needed to know if it truly reduces miscarriage risk.

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Contacts and locations

Locations

  • Bornes

    Paris, Hopital Tenon, 75020, France

  • Kayem

    Paris, Hopital Trousseau, 75012, France

  • Mekinian

    Paris, Hopital Saint Antoine, 75012, France

Conditions

The condition(s) this trial relates to.

Abortion, Spontaneous habitual spontaneous abortion

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.