New hope for transplant patients: daily IL-2 shots tame stubborn immune attack

NCT ID NCT01366092

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 26 times

Summary

This study tested whether a daily low-dose injection of IL-2 can help control chronic graft-versus-host disease (cGVHD) in 35 people who had not improved with steroids. cGVHD is a condition where donor immune cells attack the recipient's body after a stem cell or bone marrow transplant. The goal was to see if IL-2 could calm this immune response and allow patients to reduce their steroid use.

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Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02214, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02214, United States

Conditions

Explore the condition pages connected to this study.