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Can a tiny Add-On make knee surgery numbing last longer?

NCT ID NCT07807020

Symptom relief Sponsor: Shifa International Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether adding a low dose of dexmedetomidine to the standard spinal anesthetic bupivacaine can prolong pain relief during and after knee replacement surgery. Researchers will compare the duration of anesthesia and the time until the first painkiller request between patients receiving the combination and those receiving bupivacaine alone. The study includes adults aged 18 to 60 scheduled for total knee replacement, and it aims to see if the lower dose provides benefits while reducing side effects like low blood pressure or slow heart rate.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine (added to bupivacaine for spinal anesthesia)
What this could lead to
If it works, this could make spinal anesthesia last longer and improve pain control after knee replacement, while reducing the risk of low blood pressure or slow heart rate.
What could go wrong
This is an early-phase trial with only 60 participants, so results may not apply broadly. Adding dexmedetomidine to spinal anesthesia could still cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria:• Patients aged between 18 and 60 years * Classified as ASA physical status II-III * Scheduled for elective lower limb joint replacement surgeries ( total knee replacement \[TKR\]) - Written informed consent Exclusion Criteria: Allergy to study drugs * Contraindications to spinal anesthesia * History of cardiac conduction abnormalities or severe bradycardia * Neurological or psychiatric illness * Pregnancy or lactation

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intrathecal dexmedetomidine

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Shifa International Hospital Islamabad

    Islamabad, Federal, 44000, Pakistan

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