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Can a smaller calcium dose do the same job in pregnancy?

NCT ID NCT07784218

Disease control Sponsor: First People's Hospital of Hangzhou Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This trial asks whether a lower daily calcium dose (300 mg) can match the standard higher dose (600 mg) in supporting bone health during pregnancy. Pregnant women between 22 and 28 weeks of gestation will be randomly assigned to one of the two doses. Researchers will measure changes in bone density, blood calcium levels, and urine calcium to see if the lower dose is enough. They will also track side effects like constipation and check for any impact on pregnancy outcomes such as preeclampsia or preterm birth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Calcium supplement (300 mg/day vs 600 mg/day)
What this could lead to
If a lower calcium dose works as well as the standard one, it could reduce side effects like constipation and kidney strain while keeping bones and pregnancy healthy.
What could go wrong
This is a small pilot study, so results may not apply to all pregnancies. Lower calcium might not protect bone density or prevent complications as effectively as the higher dose.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

117 people

The number who actually took part.

Started

Sep 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pregnant women aged 18 to 45 years * Gestational age between 22 and 28 weeks * Body mass index (BMI) between 19.0\~28.0 kg/m2 * Willingness to comply with the study protocol and provision of informed consent Exclusion Criteria: * Known hypersensitivity or allergy to any active components or excipients of the study medications * Multifetal gestation * History of chronic constipation or functional defecation disorders prior to or during early pregnancy * Current clinical hypercalcemia, hyperuricemia, familial hyperlipidemia, or intestinal malabsorption disorders * History of prolonged extreme low-calcium diets or severe diagnosed nutritional deficiencies * History of illicit substance abuse, chronic alcoholism, heavy smoking, or excessive caffeine intake

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pregnancy

Contacts and locations

Locations

  • Hangzhou First People's Hospital

    Hangzhou, China

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