New hope for Tough-to-Treat depression: Long-Term safety trial launches

NCT ID NCT06966401

Recruiting now Symptom relief Sponsor: Neurocrine Biosciences Source: ClinicalTrials.gov ↗

First seen Apr 24, 2026 · Last updated May 16, 2026 · Updated 4 times

Summary

This study tests the long-term safety of an experimental drug called NBI-1065845 when added to standard antidepressants for people with major depression. About 850 adults who haven't gotten enough relief from current treatments will take the drug for up to a year. The main goal is to see what side effects occur and how well people tolerate the medication.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Neurocrine
RECRUITING

Sigulda, Lativa, LV-2150, Latvia
Neurocrine Clinical Site
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Huntsville, Alabama, 35801, United States
Neurocrine Clinical Site
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Bryant, Arkansas, 72022, United States
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Little Rock, Arkansas, 72204, United States
Neurocrine Clinical Site
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Glendale, California, 91206, United States
Neurocrine Clinical Site
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Los Angeles, California, 90025, United States
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Oceanside, California, 92056, United States
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Orange, California, 92866, United States
Neurocrine Clinical Site
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Pico Rivera, California, 90660, United States
Neurocrine Clinical Site
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San Diego, California, 92103-8229, United States
Neurocrine Clinical Site
TERMINATED

Upland, California, 91786, United States
Neurocrine Clinical Site
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Cromwell, Connecticut, 06416, United States
Neurocrine Clinical Site
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Farmington, Connecticut, 06030, United States
Neurocrine Clinical Site
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Hollywood, Florida, 33024, United States
Neurocrine Clinical Site
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Maitland, Florida, 32751-5669, United States
Neurocrine Clinical Site
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Maitland, Florida, 32751, United States
Neurocrine Clinical Site
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Miami, Florida, 33174, United States
Neurocrine Clinical Site
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Miami Gardens, Florida, 33014, United States
Neurocrine Clinical Site
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Palm Bay, Florida, 32905, United States
Neurocrine Clinical Site
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Tampa, Florida, 33607, United States
Neurocrine Clinical Site
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Tampa, Florida, 33629, United States
Neurocrine Clinical Site
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Atlanta, Georgia, 30318, United States
Neurocrine Clinical Site
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Gaithersburg, Maryland, 20877, United States
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Boston, Massachusetts, 02116, United States
Neurocrine Clinical Site
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Watertown, Massachusetts, 02472, United States
Neurocrine Clinical Site
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O'Fallon, Missouri, 63368, United States
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Saint Charles, Missouri, 63304, United States
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Cedarhurst, New York, 11516, United States
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Mount Kisco, New York, 10549, United States
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New York, New York, 10029, United States
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New York, New York, 10128, United States
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The Bronx, New York, 10461, United States
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Avon Lake, Ohio, 44012, United States
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Edmond, Oklahoma, 73013, United States
Neurocrine Clinical Site
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Philadelphia, Pennsylvania, 19104, United States
Neurocrine Clinical Site
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Dallas, Texas, 75251, United States
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Houston, Texas, 77030, United States
Neurocrine Clinical Site
WITHDRAWN

Richmond, Texas, 77407, United States
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Stafford, Texas, 77477, United States
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The Woodlands, Texas, 77381, United States
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Everett, Washington, 98201, United States
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Alken, 3570, Belgium
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Mechelen, 2800, Belgium
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Plovdiv, 4400, Bulgaria
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Sofia, 1113, Bulgaria
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Sofia, 1408, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1680, Bulgaria
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Varna, 9020, Bulgaria
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Zagreb, 10000, Croatia
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Zagreb, 10090, Croatia
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Pilsen, 30100, Czechia
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Prague, 100 00, Czechia
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Prague, 11000, Czechia
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Prague, 160 00, Czechia
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Prague, 186 00, Czechia
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Tallinn, 11315, Estonia
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Kuopio, 70110, Finland
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Oulu, 90100, Finland
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Tampere, 33210, Finland
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Budapest, 1036, Hungary
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Jelgava, LV-3008, Latvia
Neurocrine Clinical Site
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Liepāja, LV-3401, Latvia
Neurocrine Clinical Site
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Kaunas, LT-44279, Lithuania
Neurocrine Clinical Site
NOT_YET_RECRUITING

Amsterdam, 1081 GN, Netherlands
Neurocrine Clinical Site
NOT_YET_RECRUITING

Groningen, 9713 GZ, Netherlands
Neurocrine Clinical Site
NOT_YET_RECRUITING

Leiden, 2333 ZA, Netherlands
Neurocrine Clinical Site
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Bełchatów, 97-400, Poland
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Bialystok, 15-404, Poland
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Bialystok, 15-756, Poland
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Bydgoszcz, 85-794, Poland
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Gdansk, 80-283, Poland
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Gdansk, 80-546, Poland
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Grudziądz, 86-300, Poland
Neurocrine Clinical Site
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Katowice, 40-514, Poland
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Craiova, 200157, Romania
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Bojnice, 97201, Slovakia
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Bratislava, 820 07, Slovakia
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Košice, 04001, Slovakia
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Rimavská Sobota, 979 01, Slovakia
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Svidník, 089 01, Slovakia
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Vranov nad Topľou, 093 01, Slovakia
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Gothenburg, 41345, Sweden
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Lund, 222 22, Sweden
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Stockholm, 113 29, Sweden
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Sheffield, South Yorkshire, S3 7ND, United Kingdom
Neurocrine Clinical Site
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London, SE5 8AF, United Kingdom

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER