New eye implant shows promise for Long-Term wet AMD control

NCT ID NCT07516132

Recruiting now Disease control Sponsor: Ocular Therapeutix, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study is checking the long-term safety of an implant called OTX-TKI (axitinib) for people with wet age-related macular degeneration (AMD). The implant is placed in the eye and slowly releases medicine to control the disease. About 850 people who already completed two years of treatment in earlier studies will be followed for up to three more years. The main goal is to see if the implant remains safe over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: axitinib implant (OTX-TKI)
What this could lead to: If successful, this could show that the axitinib implant is safe for long-term use, potentially offering a treatment that reduces the need for frequent eye injections for wet AMD.
What could go wrong: This is an extension study focused on safety, not on how well the treatment works. It only includes people who already did well in earlier trials, so results may not apply to everyone with wet AMD.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD)

Contacts and locations

Locations

Austin Retina Associates
RECRUITING

Austin, Texas, 78705, United States
California Retina Consultants (CRC)
RECRUITING

Bakersfield, California, 93309, United States
California Retina Consultants (CRC)
RECRUITING

Santa Barbara, California, 93103, United States
Cumberland Valley Retina Associates
RECRUITING

Hagerstown, Maryland, 21740, United States
Mid Atlantic Retina Specialists
RECRUITING

Hagerstown, Maryland, 21740, United States
Palmetto Retina Center
RECRUITING

West Columbia, South Carolina, 29619, United States
Retina Group of Florida - Fort Lauderdale
RECRUITING

Fort Lauderdale, Florida, 33308, United States
Retina Group of New England
RECRUITING

Waterford, Connecticut, 06385, United States

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