New hope for rare heart disease: experimental drug tested for long-term safety

NCT ID NCT06260709

Ongoing Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests the long-term safety of an experimental drug called NNC6019-0001 in people with transthyretin amyloid cardiomyopathy, a rare heart disease that can lead to heart failure. All 80 participants have already completed an earlier study and will receive the drug every 4 weeks for up to 3 years. Researchers will monitor side effects and measure changes in walking ability, heart function, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NNC6019-0001
What this could lead to: If it works, this could point toward a treatment that reduces heart failure symptoms and improves daily function for people with this rare heart disease.
What could go wrong: This is a small, early-phase extension study with no placebo group, so results may not prove effectiveness. Long-term safety is still unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSTHYRETIN AMYLOID CARDIOMYOPATHY (ATTR-CM)

Contacts and locations

Locations

Ap-Hp-Hopital Henri Mondor

Créteil, 94000, France
Cedars-Sinai Medical Center_Los Angeles

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil-1

Toulouse, 31059, France
Centro per lo Studio e la Cura delle Amiloidosi Sistemiche Fondazione IRCCS Policlinico San Matteo

Pavia, PV, 27100, Italy
Ctr for Cardiovascular Innovation

Vancouver, British Columbia, V5Z 1M9, Canada
Fondazione CNR-Regione Toscana Gabriele Monasterio

Pisa, Pi, 56124, Italy
Fondazione Toscana Gabriele Monasterio - Dipartimento Cardiotoracico - UOC Cardiologia e Medicina Cardiovascolare

Pisa, Pi, 56124, Italy
Hiroshima University hospital, Cardiovascular Medicine

Hiroshima, 734-8551, Japan
Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, 28222, Spain
Hospital da Senhora da Oliveira - Guimarães

Guimarães, 4835-044, Portugal
Hospital of the University of Occupational and Environmental Health, Cardiology, Nephrology

Fukuoka, 807-8556, Japan
II. interni klinika VFN - Kardiologie a angiologie

Prague, 12808, Czechia
Kumamoto University Hospital, Cardiovascular Medicine

Kumamoto-shi, Kumamoto, 860-8556, Japan
LMU Klinikum München Klinik und Poliklinik 1

München, 81377, Germany
Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic Jacksonville

Jacksonville, Florida, 32224, United States
Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States
NW Univ-Bluhm Cardiovasc Inst

Chicago, Illinois, 60611, United States
NW Univ-Bluhm Cardiovasc Inst

Evanston, Illinois, 60208, United States
Nagasaki University Hospital, Cardiovascular Medicine

Nagasaki, 852-8501, Japan
Okayama University Hospital_Cardiovascular Medicine

Okayama-shi, Okayama, 700-8558, Japan
Shinshu University Hospital, Department of Neurology

Nagano, 390-8621, Japan
Stanford Hlth Cre-Boswell Clin

Stanford, California, 94305, United States
UMC Groningen

Groningen, 9713 GZ, Netherlands
Unidade Local De Saude De Tras-Os-Montes E Alto Douro E.P.E.

Vila Real, 5000-508, Portugal
Unidade Local de Saude do Alto Ave, E.P.E.

Guimarães, 4835-044, Portugal
Uniklinik Münster, Klinik für Kardiologie I

Münster, 48149, Germany
UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie

Heidelberg, 69120, Germany
Univ of MD Schl of Med

Baltimore, Maryland, 21201, United States
Universitair Medisch Centrum Utrecht

Utrecht, 3584 CX, Netherlands
Universitatsklinikum Wurzburg AöR

Würzburg, 97078, Germany
Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz

Würzburg, 97078, Germany
University of Calgary_Cardiology

Calgary, Alberta, T2N 4Z6, Canada
Universitätsklinik Heidelberg Innere Medizin III Kardiologie, Angiologie, Pneumologie

Heidelberg, 69120, Germany
Universitätsklinikum Münster - Klinik für Kardiologie I

Münster, 48149, Germany

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