Hope for myotonic dystrophy: new drug shows promise in easing muscle stiffness Long-Term
NCT ID NCT06549400
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing the long-term safety and effectiveness of a drug called mexiletine PR for people with myotonic dystrophy types 1 and 2. The drug is taken once daily as a liquid to help reduce muscle stiffness (myotonia). The study includes 176 adults and teens who have already completed a previous trial. Researchers will measure how quickly hand muscles relax after a strong squeeze and track any side effects over 26 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mexiletine PR (prolonged-release granules for oral suspension)
What this could lead to
If successful, this could confirm a safe, long-term treatment option to reduce muscle stiffness and improve daily function for people with myotonic dystrophy.
What could go wrong
This is an extension study, so participants already tolerated the drug; however, long-term side effects are still being monitored, and the results may not apply to all patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aarhus University Hospital
Aarhus, Denmark
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Azienda Ospedaliera Universitaria Policlinico Tor Vergata
Rome, Italy
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Laboratory for Muscle Diseases and Neuropathies
Leuven, Belgium
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Ludug-Maximilians University
München, Germany
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University College Hospital
London, United Kingdom
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University Hospital of Madrid
Madrid, Spain