Knee OA drug trial ends early – what happened?

NCT ID NCT04520607

Terminated Disease control Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Mar 26, 2026 · Last updated May 12, 2026 · Updated 4 times

Summary

This study looked at the long-term safety and effectiveness of lorecivivint, an experimental drug for knee osteoarthritis. It enrolled 276 adults who had already completed a previous study. The trial was terminated early, so results are limited. The goal was to see if the drug could help manage pain and joint function over two years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Tucson, Arizona, 85712, United States
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Anaheim, California, 92805, United States
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Pomona, California, 91767, United States
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San Diego, California, 92103, United States
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Thousand Oaks, California, 91360, United States
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Denver, Colorado, 80209, United States
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Hialeah, Florida, 33016, United States
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Miami, Florida, 33173, United States
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Miami Lakes, Florida, 33014, United States
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Port Orange, Florida, 32127, United States
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West Palm Beach, Florida, 33409, United States
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Winter Haven, Florida, 33880, United States
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Winter Park, Florida, 32789, United States
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Newnan, Georgia, 30265, United States
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Woodstock, Georgia, 30189, United States
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Gurnee, Illinois, 60031, United States
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Oak Brook, Illinois, 60523, United States
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Valparaiso, Indiana, 46383, United States
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New Orleans, Louisiana, 70124, United States
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Bay City, Michigan, 48706, United States
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Troy, Michigan, 48085, United States
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Hazelwood, Missouri, 63042, United States
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St Louis, Missouri, 63141, United States
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Omaha, Nebraska, 68114, United States
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Hartsdale, New York, 10530, United States
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New York, New York, 10016, United States
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Rochester, New York, 14609, United States
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Charlotte, North Carolina, 28209, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Cincinnati, Ohio, 45242, United States
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Columbus, Ohio, 43235, United States
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Oklahoma City, Oklahoma, 73103, United States
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Fort Mill, South Carolina, 29707, United States
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Mt. Pleasant, South Carolina, 29464, United States
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Rapid City, South Dakota, 57702, United States
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Carrollton, Texas, 75007, United States
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Plano, Texas, 75075, United States
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San Antonio, Texas, 78229, United States
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Draper, Utah, 84020, United States
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Salt Lake City, Utah, 84107, United States
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Charlottesville, Virginia, 22911, United States

Conditions

Explore the condition pages connected to this study.

OSTEOARTHRITIS, KNEE