New drug shows promise for controlling dangerous fat levels in the blood

NCT ID NCT06822790

Recruiting now Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 28 times

Summary

This study is for adults with very high triglycerides, a type of fat in the blood that can increase the risk of pancreatitis and heart disease. Participants who completed a previous related study can join and will receive injections of plozasiran every 3 months for 2 years. The goal is to see if the drug is safe and keeps triglyceride levels low over the long term.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Research Site 1
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Miami Lakes, Florida, 33014, United States
Research Site 10
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Manassas, Virginia, 20110, United States
Research Site 100
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Dimitrovgrad, 6400, Bulgaria
Research Site 101
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Sarnia, Ontario, N7T 4X3, Canada
Research Site 102
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Waterloo, Ontario, N2T 0C1, Canada
Research Site 103
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Halifax, Nova Scotia, NS B3H 1V7, Canada
Research Site 104
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Beijing, Beijing Municipality, 100034, China
Research Site 105
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Yuncheng, Shanxi, 44000, China
Research Site 106
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Xingtai, Hebei, 054099, China
Research Site 107
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Changsha, Hu'nan, 410011, China
Research Site 108
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Changsha, Hu'nan, 410015, China
Research Site 109
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Wenzhou, Zhejiang, 325000, China
Research Site 11
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Canoga Park, California, 91303, United States
Research Site 110
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Nanchang, Jiangxi, 330006, China
Research Site 111
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Guangzhou, Guangdong, 510180, China
Research Site 112
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Guangzhou, Guangdong, 510080, China
Research Site 113
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Chengdu, Sichuan, 610072, China
Research Site 114
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Liuzhou, Guangxi Zhuang, 545006, China
Research Site 115
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Baotou, Inner Mongolia, 014010, China
Research Site 116
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Praha 4-Krc, 140 59, Czechia
Research Site 117
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Hodonín, 69501, Czechia
Research Site 118
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Olomouc, CZ77900, Czechia
Research Site 119
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Prague, 11000, Czechia
Research Site 12
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Annapolis, Maryland, 21401, United States
Research Site 120
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Pessac, Gironde, 33604, France
Research Site 121
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Pécs, 7623, Hungary
Research Site 122
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Budapest, 1132, Hungary
Research Site 123
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Budapest, 1051, Hungary
Research Site 124
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Daugavpils, LV-5417, Latvia
Research Site 125
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Riga, LV1063, Latvia
Research Site 126
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Kaunas, 49387, Lithuania
Research Site 127
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Šiauliai, LT-76206, Lithuania
Research Site 128
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Christchurch, 08011, New Zealand
Research Site 129
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Wellington, 6021, New Zealand
Research Site 13
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Sugar Land, Texas, 77479, United States
Research Site 130
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Elblag, 82-300, Poland
Research Site 131
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Lodz, 94-255, Poland
Research Site 132
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Malbork, 82-200, Poland
Research Site 133
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Wroclaw, 51-314, Poland
Research Site 134
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Katowice, 40-156, Poland
Research Site 135
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Szczecin, 71- 500, Poland
Research Site 136
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Lodz, 91-363, Poland
Research Site 137
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Żarów, 58-130, Poland
Research Site 138
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Krakow, 31-501, Poland
Research Site 139
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Warsaw, 00-215, Poland
Research Site 14
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Hialeah, Florida, 33016, United States
Research Site 140
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Wroclaw, 53-673, Poland
Research Site 141
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Katowice, 40-752, Poland
Research Site 142
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Bucharest, 010192, Romania
Research Site 143
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Ploieşti, 100342, Romania
Research Site 144
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Târgu Mureş, 540136, Romania
Research Site 145
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Timișoara, 300362, Romania
Research Site 146
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Košice, 04001, Slovakia
Research Site 147
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Bardejov, 08501, Slovakia
Research Site 148
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Rožňava, 048 01, Slovakia
Research Site 149
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Somerset West, Western Cape, 7130, South Africa
Research Site 15
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Bountiful, Utah, 84010, United States
Research Site 150
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Seville, 41013, Spain
Research Site 151
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Zaragoza, 50009, Spain
Research Site 152
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Plymouth, Devon, PL5 3JB, United Kingdom
Research Site 153
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Torquay, Devon, TQ2 7AA, United Kingdom
Research Site 154
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Miami, Florida, 33144, United States
Research Site 155
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Fort Lauderdale, Florida, 33308, United States
Research Site 156
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Long Island City, New York, 11106, United States
Research Site 157
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Indianapolis, Indiana, 46290, United States
Research Site 158
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Houston, Texas, 77061, United States
Research Site 159
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Orlando, Florida, 32825, United States
Research Site 16
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Tamarac, Florida, 33321, United States
Research Site 160
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Fort Worth, Texas, 76132, United States
Research Site 161
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Plano, Texas, 75093, United States
Research Site 162
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Mt. Dora, Florida, 32757, United States
Research Site 163
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Houston, Texas, 77090, United States
Research Site 164
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Norman, Oklahoma, 73072, United States
Research Site 165
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Summit, New Jersey, 07901, United States
Research Site 166
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Baltimore, Maryland, 21229, United States
Research Site 167
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Elkhart, Indiana, 46514-2487, United States
Research Site 168
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San Antonio, Texas, 78230, United States
Research Site 169
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Wilmington, North Carolina, 28401, United States
Research Site 17
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Park Ridge, Illinois, 60068, United States
Research Site 170
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Tomball, Texas, 77375, United States
Research Site 171
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Córdoba, X5000AAW, Argentina
Research Site 172
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Ciudad Autonoma Buenos Aires, 1425, Argentina
Research Site 173
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Ciudad Autonoma Buenos Aires, C1430CKE, Argentina
Research Site 174
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Nedlands, Western Australia, 6009, Australia
Research Site 175
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Roeselare, 8800, Belgium
Research Site 176
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Votuporanga, São Paulo, 15500-269, Brazil
Research Site 177
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São Paulo, 04266-010, Brazil
Research Site 178
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Belo Horizonte, Minas Gerais, 30150-274, Brazil
Research Site 179
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São Paulo, 05403-900, Brazil
Research Site 18
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Tampa, Florida, 33614, United States
Research Site 180
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Campinas, São Paulo, 13060-080, Brazil
Research Site 181
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Aracaju, Sergipe, 49055-530, Brazil
Research Site 182
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Sofia, 1431, Bulgaria
Research Site 183
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Sofia, 1431, Bulgaria
Research Site 184
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Sofia, 1527, Bulgaria
Research Site 185
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Plovdiv, 4001, Bulgaria
Research Site 186
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Sofia, 1431, Bulgaria
Research Site 187
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Burgas, 8000, Bulgaria
Research Site 188
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Luoyang, Henan, 471003, China
Research Site 189
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Shanghai, Shanghai Municipality, 200050, China
Research Site 19
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Québec, G1G5X1, Canada
Research Site 190
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Liaocheng, Shandong, 252000, China
Research Site 191
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Bengbu, Anhui, 233004, China
Research Site 192
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Suzhou, Jiangsu, 215002, China
Research Site 193
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Beijing, Beijing Municipality, 100091, China
Research Site 194
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Zagreb, 10000, Croatia
Research Site 195
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Ústí nad Labem, 40113, Czechia
Research Site 196
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Trutnov, 541 01, Czechia
Research Site 197
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Hradec Králové, 50005, Czechia
Research Site 198
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Teplice, 41501, Czechia
Research Site 199
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Marseille, Bouches-du-Rhône, 13005, France
Research Site 2
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Jefferson City, Missouri, 65109, United States
Research Site 20
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Victoria, British Columbia, V8T5G4, Canada
Research Site 200
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Paris, Paris, 75013, France
Research Site 201
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Magdeburg, Saxony-Anhalt, 39120, Germany
Research Site 202
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Veszprém, 8200, Hungary
Research Site 203
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Zalaegerszeg, 8900, Hungary
Research Site 204
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Budapest, 1033, Hungary
Research Site 205
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Miskolc, 3530, Hungary
Research Site 206
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Roma, 00168, Italy
Research Site 207
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Milan, 20162, Italy
Research Site 208
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Brescia, 25123, Italy
Research Site 209
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Rozzano, Milano, 20089, Italy
Research Site 21
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Bakersfield, California, 93311, United States
Research Site 210
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Palermo, 90127, Italy
Research Site 211
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Riga, LV-1002, Latvia
Research Site 212
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Daugavpils, LV-5410, Latvia
Research Site 213
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Kaunas, LT-50177, Lithuania
Research Site 214
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Vilnius, LT-08661, Lithuania
Research Site 215
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Zamość, 22-400, Poland
Research Site 216
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Warsaw, 03-291, Poland
Research Site 217
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Galati, 800291, Romania
Research Site 218
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Moldava nad Bodvou, 045 01, Slovakia
Research Site 219
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Krugersdorp, Gauteng, 1739, South Africa
Research Site 22
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Beavercreek, Ohio, 45431, United States
Research Site 220
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Cape Town, Western Cape, 7570, South Africa
Research Site 221
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Cape Town, Western Cape, 7925, South Africa
Research Site 222
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Cape Town, Western Cape, 7500, South Africa
Research Site 223
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Barcelona, 08035, Spain
Research Site 224
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A Coruña, La Coruña, 15006, Spain
Research Site 225
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Valencia, 46010, Spain
Research Site 226
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Madrid, 28041, Spain
Research Site 227
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London, Greater London, EC1M 6BQ, United Kingdom
Research Site 228
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New York, New York, 10029, United States
Research Site 229
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Palm Springs, California, 92262, United States
Research Site 23
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Topeka, Kansas, 66606, United States
Research Site 230
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Missouri City, Texas, 77459, United States
Research Site 231
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Philadelphia, Pennsylvania, 19104, United States
Research Site 232
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St Louis, Missouri, 63136, United States
Research Site 233
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New York, New York, 10016, United States
Research Site 234
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Columbus, Ohio, 43214, United States
Research Site 235
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Huntington Beach, California, 92648, United States
Research Site 236
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Lake Forest, California, 92630, United States
Research Site 237
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Lawrenceville, Georgia, 30044, United States
Research Site 238
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Fort Mill, South Carolina, 29707, United States
Research Site 239
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Córdoba, X5006CBI, Argentina
Research Site 24
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Houston, Texas, 77095, United States
Research Site 240
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Córdoba, X5008HHW, Argentina
Research Site 241
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Toronto, Ontario, M5G 2C4, Canada
Research Site 242
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Tianjin, Tianjin Municipality, 300121, China
Research Site 243
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Shanghai, Shanghai Municipality, 200040, China
Research Site 244
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Prague, 140 21, Czechia
Research Site 245
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Bologna, 40138, Italy
Research Site 246
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Kaunas, 49449, Lithuania
Research Site 247
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Gdynia, 81-338, Poland
Research Site 248
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Nitra, 950 01, Slovakia
Research Site 25
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Victoria, Texas, 77901, United States
Research Site 26
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Horsham, Pennsylvania, 19044, United States
Research Site 27
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El Paso, Texas, 19044, United States
Research Site 28
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Overland Park, Kansas, 66211, United States
Research Site 29
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Fremont, Nebraska, 68025, United States
Research Site 3
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Omaha, Nebraska, 68144, United States
Research Site 30
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Flint, Michigan, 48532, United States
Research Site 31
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Oklahoma City, Oklahoma, 73112, United States
Research Site 32
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Olive Branch, Mississippi, 38654, United States
Research Site 33
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Jackson, Mississippi, 39202, United States
Research Site 34
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Oxnard, California, 93030, United States
Research Site 35
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St. George, Utah, 84790, United States
Research Site 36
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Morehead City, North Carolina, 28557, United States
Research Site 37
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Asheboro, North Carolina, 27203, United States
Research Site 38
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North Miami, Florida, 33162, United States
Research Site 39
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Lincoln, California, 95648, United States
Research Site 4
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Québec, Quebec, G1V 4W2, Canada
Research Site 40
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Garden Grove, California, 92844, United States
Research Site 41
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Orlando, Florida, 32825, United States
Research Site 42
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Mt. Dora, Florida, 32757, United States
Research Site 43
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Elkhart, Indiana, 46514, United States
Research Site 44
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Baltimore, Maryland, 21229, United States
Research Site 45
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Wetteren, 9230, Belgium
Research Site 46
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Namur, 5000, Belgium
Research Site 47
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Mechelen, 2800, Belgium
Research Site 48
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Gozée, 6534, Belgium
Research Site 49
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Pleven, 5800, Bulgaria
Research Site 5
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Montreal, Quebec, H2W 1R7, Canada
Research Site 50
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Plovdiv, 4002, Bulgaria
Research Site 51
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Sofia, 1616, Bulgaria
Research Site 52
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Kyustendil, 2500, Bulgaria
Research Site 53
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Sofia, 1404, Bulgaria
Research Site 54
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Kardzhali, 6600, Bulgaria
Research Site 55
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Sarnia, Ontario, N7T 4X3, Canada
Research Site 56
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Kitchener, N2H5Z8, Canada
Research Site 57
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Beijing, Beijing Municipality, 100034, China
Research Site 58
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Yuncheng, Shanxi, 44000, China
Research Site 59
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Changsha, Hu'nan, 410011, China
Research Site 6
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Chicoutimi, Quebec, G7H 7K9, Canada
Research Site 60
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Wenzhou, Zhejiang, 325000, China
Research Site 61
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Nanchang, Jiangxi, 330006, China
Research Site 62
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Guangzhou, Guangdong, 510000, China
Research Site 63
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Liuzhou, Guangxi Zhuang, 545006, China
Research Site 64
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Baotou, Inner Mongolia, 14010, China
Research Site 65
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Hodonín, 69501, Czechia
Research Site 66
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Prague, 11000, Czechia
Research Site 67
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Pécs, 7623, Hungary
Research Site 68
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Budapest, 1132, Hungary
Research Site 69
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Riga, LV1063, Latvia
Research Site 7
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London, Ontario, N6A 5K8, Canada
Research Site 70
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Kaunas, 49387, Lithuania
Research Site 71
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Plymouth, Devon, PL5 3JB, United Kingdom
Research Site 72
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Long Island City, New York, 11106, United States
Research Site 73
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Houston, Texas, 77061, United States
Research Site 74
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Plano, Texas, 75093, United States
Research Site 75
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Houston, Texas, 77090, United States
Research Site 76
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Norman, Oklahoma, 73072, United States
Research Site 77
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Summit, New Jersey, 07901, United States
Research Site 78
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Elblag, 82-300, Poland
Research Site 79
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Lodz, 94-255, Poland
Research Site 8
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Newport, Pennsylvania, 17074, United States
Research Site 80
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Malbork, 82-200, Poland
Research Site 81
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Katowice, 40-156, Poland
Research Site 82
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Żarów, 58-130, Poland
Research Site 83
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Krakow, 31-501, Poland
Research Site 84
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Warsaw, 00-215, Poland
Research Site 85
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Katowice, 40-752, Poland
Research Site 86
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Box Hill, Victoria, 3128, Australia
Research Site 87
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Hasselt, 3500, Belgium
Research Site 88
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Wetteren, 9230, Belgium
Research Site 89
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Namur, 5380, Belgium
Research Site 9
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Beverly Hills, California, 90211, United States
Research Site 90
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Mechelen, 97770, Belgium
Research Site 91
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Gozée, 6534, Belgium
Research Site 92
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Pleven, 5800, Bulgaria
Research Site 93
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Plovdiv, 4002, Bulgaria
Research Site 94
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Rousse, 7013, Bulgaria
Research Site 95
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Sofia, 1616, Bulgaria
Research Site 96
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Kyustendil, 2500, Bulgaria
Research Site 97
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Sofia, 1618, Bulgaria
Research Site 98
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Kardzhali, 6600, Bulgaria
Research Site 99
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Stara Zagora, 6010, Bulgaria

Conditions

Explore the condition pages connected to this study.

HYPERTRIGLYCERIDEMIA