Epidiolex liver check: is Long-Term use safe?

NCT ID NCT05044819

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 5 times

Summary

This study follows 154 people taking Epidiolex (cannabidiol) for seizures caused by Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex. Researchers will monitor for signs of chronic liver injury and fibrosis over time using blood tests and liver scans. The goal is to understand the long-term liver safety of this medication.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Cannabidiol (Epidiolex) oral solution
What this could lead to
If successful, this study could confirm that long-term use of Epidiolex is safe for the liver, reassuring patients and doctors.
What could go wrong
This is an observational safety study, not a test of effectiveness. It may find liver risks that limit use, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Clinical Trial Site

    Little Rock, Arkansas, 72758, United States

  • Clinical Trial Site

    Downey, California, 90242, United States

  • Clinical Trial Site

    Long Beach, California, 90806, United States

  • Clinical Trial Site

    Sacramento, California, 95817, United States

  • Clinical Trial Site

    Miami, Florida, 33136, United States

  • Clinical Trial Site

    Miami, Florida, 33176, United States

  • Clinical Trial Site

    Orlando, Florida, 32806, United States

  • Clinical Trial Site

    Tampa, Florida, 33606, United States

  • Clinical Trial Site

    Augusta, Georgia, 30912, United States

  • Clinical Trial Site

    Wichita, Kansas, 67214, United States

  • Clinical Trial Site

    Lexington, Kentucky, 40504, United States

  • Clinical Trial Site

    Baltimore, Maryland, 21205, United States

  • Clinical Trial Site

    Boston, Massachusetts, 02114, United States

  • Clinical Trial Site

    New Brunswick, New Jersey, 08901, United States

  • Clinical Trial Site

    New York, New York, 10016, United States

  • Clinical Trial Site

    Charlotte, North Carolina, 28203, United States

  • Clinical Trial Site

    Durham, North Carolina, 27708, United States

  • Clinical Trial Site

    Cincinnati, Ohio, 45219, United States

  • Clinical Trial Site

    Oklahoma City, Oklahoma, 73104, United States

  • Clinical Trial Site

    Philadelphia, Pennsylvania, 19107, United States

  • Clinical Trial Site

    Charleston, South Carolina, 29425, United States

  • Clinical Trial Site

    Austin, Texas, 78758, United States

  • Clinical Trial Site

    Dallas, Texas, 75251, United States

  • Clinical Trial Site

    Houston, Texas, 77030, United States

  • Clinical Trial Site

    Round Rock, Texas, 78681, United States

  • Clinical Trial Site

    Winchester, Virginia, 22601, United States

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