Gene therapy for radiation dry mouth tracked long-term
NCT ID NCT06544798
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows adults who previously received a gene therapy (AAV2-hAQP1) for dry mouth caused by radiation treatment for head and neck cancers. Researchers will check for side effects and how well the therapy works over time. About 276 people who already got the therapy in an earlier study will take part.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
About 276 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Aug 2024
- Expected to finish
-
Feb 2032
An estimate. End dates often move.
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Received study drug in Study MGT-AQP1-201 Exclusion Criteria: * Withdrew consent to participate in Study MGT-AQP1-201.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Grade 2 and 3 late xerostomia caused by radiotherapy for cancers of the upper aerodigestive tract, excluding the parotid glands are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
8 sites in 2 countries. The list below names each one and where it is.
-
The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Alleghany General Hospital
Pittsburgh, Pennsylvania, 15212, United States
-
Atrium Health
Charlotte, North Carolina, 28209, United States
-
Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
-
Erie County Medical Center
Buffalo, New York, 14215, United States
-
Miami Cancer Institute at Baptist Health South Florida
Miami, Florida, 33176, United States
-
Shirley and Jim Fielding Northeast Cancer Centre - Health Sciences North
Greater Sudbury, Ontario, P3E 5J1, Canada
-
University of Iowa
Iowa City, Iowa, 52242, United States
-
University of Missouri
Columbia, Missouri, 65212, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.