Gene therapy for radiation dry mouth: long-term safety check underway

NCT ID NCT06544798

ENROLLING_BY_INVITATION Disease control Sponsor: MeiraGTx, LLC Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 26 times

Summary

This study follows adults who previously received a gene therapy (AAV2-hAQP1) for dry mouth caused by radiation treatment for head and neck cancers. Researchers will monitor participants for long-term side effects and how well the therapy continues to work. The goal is to see if this one-time treatment safely helps manage dry mouth over time.

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Contacts and locations

Locations

  • Alleghany General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Atrium Health

    Charlotte, North Carolina, 28209, United States

  • Banner MD Anderson Cancer Center

    Gilbert, Arizona, 85234, United States

  • Erie County Medical Center

    Buffalo, New York, 14215, United States

  • Miami Cancer Institute at Baptist Health South Florida

    Miami, Florida, 33176, United States

  • Shirley and Jim Fielding Northeast Cancer Centre - Health Sciences North

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

Conditions

Explore the condition pages connected to this study.