Gene therapy could restore saliva flow in dry mouth sufferers
NCT ID NCT05926765
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This study tests a gene therapy (AAV2-hAQP1) injected into the saliva glands to see if it can safely increase saliva production in people with long-term dry mouth after radiation for head and neck cancer. About 276 adults who completed radiation at least 3 years ago will receive either the gene therapy or a placebo. The main goal is to measure changes in dry mouth symptoms and saliva flow over 12 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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Contacts and locations
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Locations
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Addenbrooke's Hospital
Cambridge, United Kingdom
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Alleghany General Hospital
Pittsburgh, Pennsylvania, 15212, United States
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Atrium Health
Charlotte, North Carolina, 28203, United States
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02120, United States
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CIUSSS-MCQ (Trois-Rivières, QC)
Trois-Rivières, G8Z 3R9, Canada
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Cardiff and Vale NHS Trust - Head & Neck Services
Cardiff, CF14 4XW, United Kingdom
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City of Hope
Duarte, California, 91010, United States
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Erie County Medical Center
Buffalo, New York, 14215, United States
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Glasgow Royal Infirmary
Glasgow, LS2 9LU, United Kingdom
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Guys Hospital
London, SE1 9RT, United Kingdom
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Henry Ford Health
Detroit, Michigan, 48202, United States
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Hopital Fleurimont, CIUSSS de l'Estrie-CHUS
Québec, J1H 5HE, Canada
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Houston Methodist
Houston, Texas, 77030, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21231, United States
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Johnson City Medical Center
Johnson City, Tennessee, 37604, United States
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Leeds Dental Institute
Leeds, LS2 9LU, United Kingdom
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Miami Cancer Institute at Baptist Health South Florida
Miami, Florida, 33176, United States
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Ninewells Hospital & Medical School
Dundee, DD1 9SY, United Kingdom
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Nottingham University Hospitals NHS Trust
Nottingham, NG7 2UH, United Kingdom
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Penn State
Hershey, Pennsylvania, 17033, United States
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Princess Margaret Cancer Centre
Toronto, M5G 2C4, Canada
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Shirley and Jim Fielding Northeast Cancer Centre - Health Sciences North
Greater Sudbury, Ontario, P3E 5J1, Canada
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The Royal Marsden
London, SW3 6JJ, United Kingdom
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Tufts University School of Dental Medicine
Boston, Massachusetts, 02111, United States
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UNC-Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University College London Hospitals NHS Foundation Trust
London, WC1E 6DG, United Kingdom
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Missouri
Columbia, Missouri, 65212, United States
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Washington University - St. Louis
St Louis, Missouri, 63110, United States
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Western General
London, EH4 2XU, United Kingdom
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York Hospital
York, YO31 8HE, United Kingdom
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