New drug combo shows promise for Tough-to-Treat lymphoma
NCT ID NCT05249959
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether the drug loncastuximab tesirine, given after a short course of chemotherapy, can help people with mantle cell lymphoma whose cancer has returned or not responded to previous treatments, including BTK inhibitors. About 49 participants will receive the treatment, and researchers will measure how long the disease stays under control. The goal is to find a more effective option for this hard-to-treat cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
loncastuximab tesirine (ADCT-402) given after a short course of immunochemotherapy (rituximab, bendamustine, cytarabine)
What this could lead to
If successful, this could provide a new treatment option for patients with mantle cell lymphoma that has returned or not responded to prior therapies, potentially delaying disease progression.
What could go wrong
This is a small, early-phase (phase 2) study with only 49 participants, so results may not apply broadly. The drug combination may cause significant side effects, and it is not yet known if it improves survival compared to existing treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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ASST Spedali Civili di Brescia
RECRUITINGBrescia, Italy, 25123, Italy
Contact Email: •••••@•••••
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Dipartimento di Medicina Traslazionale e di Precisione - Policlinico Umberto I - Università "La Sapienza" Istituto Ematologia
RECRUITINGRoma, 00161, Italy
Contact Email: •••••@•••••
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Divisione di Ematologia - A.O. Ospedali Riuniti Villa Sofia-Cervello
RECRUITINGPalermo, 90146, Italy
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Divisione di Ematologia - IRCCS Policlinico S. Matteo di Pavia
RECRUITINGPavia, 27100, Italy
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Ematologia - Azienda Unitа Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova
RECRUITINGReggio Emilia, 42123, Italy
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Ematologia - Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
RECRUITINGMilan, 20133, Italy
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Ematologia - Ospedale Policlinico San Martino S.S.R.L. - IRCCS per l'Oncologia
RECRUITINGGenova, 16132, Italy
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Ematologia - Ospedale delle Croci
RECRUITINGRavenna, 48121, Italy
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S.C di Ematologia - Ospedale Ca Foncello
RECRUITINGTreviso, 31100, Italy
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S.C. Ematologia - A.S.O. "SS Antonio e Biagio e Cesare Arrigo"
RECRUITINGAlessandria, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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S.C. Ematologia - ASST Grande Ospedale Metropolitano Niguarda
RECRUITINGMilan, 20162, Italy
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S.C. Ematologia Universitaria - A.O.U. Città della Salute e della Scienza di Torino
RECRUITINGTorino, 10126, Italy
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S.C. di Ematologia - A.O. S. Croce e Carle
RECRUITINGCuneo, 12100, Italy
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SC Ematologia - Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI)
RECRUITINGTrieste, 34121, Italy
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SCDU Ematologia - AOU Maggiore della Carità di Novara
RECRUITINGNovara, 28100, Italy
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U.O. Ematologia - AOU Integrata di Verona
RECRUITINGVerona, 37134, Italy
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U.O. Ematologia - Istituto Clinico Humanitas
RECRUITINGRozzano, 20089, Italy
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U.O. di Ematologia - Ospedale degli Infermi di Rimini
RECRUITINGRimini, 47923, Italy
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U.O.C Ematologia e Trapianto - A.O. C. Panico
RECRUITINGTricase, 73039, Italy
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UOC Ematologia Oncologica - Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale
RECRUITINGNaples, 80131, Italy
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Unità funzionale di Ematologia - Azienda Ospedaliera Universitaria Careggi
RECRUITINGFlorence, 50141, Italy
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