Could a second round of radiation boost survival in returning brain tumors?

NCT ID NCT05904119

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a second round of radiation to the chemotherapy drug lomustine helps people with recurrent glioblastoma live longer. About 411 adults whose brain tumor has returned after standard treatment will be randomly assigned to get lomustine alone or lomustine plus targeted radiation. The goal is to see if the combination improves overall survival without harming quality of life.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • A.O Landeskrankenhaus - Innsbruck Universitaetsklinik

    RECRUITING

    Innsbruck, 6020, Austria

  • AZORG

    RECRUITING

    Aalst, 9300, Belgium

  • Aarhus University Hospitals - Region Midtjylland - Aarhus University Hospital-Skejby

    RECRUITING

    Aarhus, 8200, Denmark

  • Assistance Publique Hopitaux Paris- APHP - APHP Nord - Univ De Paris Cite - Hop. Saint Louis

    RECRUITING

    Paris, France

  • Assistance Publique Hopitaux Paris- APHP - APHP Sorbonne Univ - Hopital la Pitie-Salpetriere (233)

    RECRUITING

    Paris, 75013, France

  • Azienda ospedaliero Univ Policlinico Umberto I

    RECRUITING

    Roma, 00161, Italy

  • CHRU de Lille

    RECRUITING

    Lille, 59037, France

  • CHU d'Amiens - CHU Amiens Picardie - Site Sud

    RECRUITING

    Amiens, 80054, France

  • CHU de Lyon - CHU Lyon - Hopital neurologique Pierre Wertheimer

    RECRUITING

    Lyon, France

  • CHU de Nice - Hôpital Pasteur

    RECRUITING

    Nice, 06000, France

  • CLCC - Jean Perrin

    RECRUITING

    Clermont-Ferrand, 63000, France

  • Cliniques Universitaires Saint-Luc

    RECRUITING

    Brussels, 1200, Belgium

  • ETZ Tilburg - ETZ - St. Elisabethziekenhuis

    RECRUITING

    Tilburg, 5022, Netherlands

  • Erasmus MC

    RECRUITING

    Rotterdam, Netherlands

  • Grand Hopital de Charleroi - Site Les Viviers

    RECRUITING

    Gilly, 6060, Belgium

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • ICO L'Hospitalet - Hospital Duran i Reynals (Institut Catala D'Oncologia)

    RECRUITING

    L'Hospitalet de Llobregat, 08908, Spain

  • IRCCS - Istituto Oncologico Veneto

    RECRUITING

    Padova, 35128, Italy

  • IRCCS-Ospedale Bellaria-Bologna

    RECRUITING

    Bologna, 40139, Italy

  • Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia) (381)

    RECRUITING

    Badalona, 08916, Spain

  • Institut Public De Cancerologie Strauss Europe-Strauss Institute

    RECRUITING

    Strasbourg, 67200, France

    Contact

  • Institut de Cancerologie de l´Ouest (ICO) - Saint Herblain

    RECRUITING

    Saint-Herblain, 44805, France

  • Institut du Cancer de Montpellier

    RECRUITING

    Montpellier, France

  • Istituto Clinico Humanitas

    RECRUITING

    Milan, 20089, Italy

  • Kepler University Hospital - Neuromed campus

    RECRUITING

    Linz, 4020, Austria

  • Leiden University Medical Centre

    RECRUITING

    Leiden, Netherlands

  • Ludwig-Maximilians-Universitaet Muenchen - Campus Grosshadern

    RECRUITING

    Munich, 81377, Germany

  • Masaryk Memorial Cancer Institute

    RECRUITING

    Brno, Czechia

  • Oncology Institute of Southern Switzerland (IOSI) - Ospedale San Giovanni

    RECRUITING

    Bellinzona, 6500, Switzerland

  • Oslo University Hospital - Radiumhospitalet

    RECRUITING

    Oslo, NO 0379, Norway

  • St Olavs University Hospital - St. Olavs Hospital, Trondheim University Hospital

    RECRUITING

    Trondheim, NO 7030, Norway

  • U.Z. Leuven - Campus Gasthuisberg

    RECRUITING

    Leuven, 3000, Belgium

  • ULSS 9 Scaligera Veneto - Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital

    RECRUITING

    Legnago, 37045, Italy

  • Univ. Knappschaft Krankenhaus Bochum

    RECRUITING

    Bochum, 44892, Germany

  • UniversitaetsSpital Zurich - Neurology Clinic

    RECRUITING

    Zurich, 8091, Switzerland

    Contact

  • Universitaetskliniken Regensburg - Universitaetsklinikum Regensburg

    TERMINATED

    Regensburg, 93053, Germany

  • Universitaetsklinikum - Essen

    RECRUITING

    Essen, 45147, Germany

    Contact

  • Universitaetsklinikum Erlangen-Schwabachanlage

    TERMINATED

    Erlangen, Germany

  • Universitaetsklinikum Heidelberg - UniversitaetsKlinikum Heidelberg - Head Hospital

    RECRUITING

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Koeln

    RECRUITING

    Cologne, 50937, Germany

  • Universitaetsklinikum Tuebingen- Crona Kliniken

    RECRUITING

    Tübingen, 72076, Germany

  • Universitaetsklinikum Wien - AKH unikliniken

    RECRUITING

    Vienna, Austria

  • Universitair Ziekenhuis Gent

    RECRUITING

    Ghent, 9000, Belgium

  • Universitätsklinikum Leipzig-Klinik für Strahlentherapie und Radioonkologie

    TERMINATED

    Leipzig, 04103, Germany

  • Ziekenhuis aan de Stroom (ZAS) - ZAS Augustinus (previous GZA)

    RECRUITING

    Wilrijk, 2610, Belgium

    Contact