New combo approach before surgery may improve outcomes for massive liver tumors

NCT ID NCT07639294

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at 715 patients with very large liver cancers (over 10 cm) to see if giving a combination of local treatments (like chemo directly into the liver) and body-wide treatments (targeted drugs and immunotherapy) before surgery helps them live longer. Patients were divided into groups based on whether they got this pre-surgery therapy or had surgery right away. The goal was to compare survival and safety between the approaches.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430030, China