New drug combo shows promise for Hard-to-Treat cancers

NCT ID NCT05199753

Completed Disease control Sponsor: LaNova Australia Pty Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-phase trial tested an experimental drug called LM-108, alone or combined with another immunotherapy, in 78 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looked for early signs that the drug might shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LM-108 (an experimental drug) and an anti-PD-1 antibody (a type of immunotherapy)
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is a very early, first-in-human trial with only 78 participants, so the main goal is safety, not effectiveness. The drug may not shrink tumors or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

Alfred Hospital

Melbourne, Victoria, VIC 3004, Australia
Blacktown Hospital

Sydney, New South Wales, NSW 2148, Australia
Cabrini Health Limited

Malvern, Victoria, VIC 3144, Australia
ICON Cancer Centre

South Brisbane, Queensland, QLD 4101, Australia
One Clinical Research Pty Ltd.

Nedlands, Western Australia, WA 6009, Australia
Sunshine Coast University Private Hospital

Birtinya, Queensland, QLD 4575, Australia

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