New Immune-Targeting drug combo takes on advanced cancers
NCT ID NCT06825494
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new drug called LM-108, which clears certain immune cells from tumors, combined with standard chemotherapy and another immunotherapy. The goal is to see if this mix is safe and can slow or shrink advanced solid tumors. About 194 adults with advanced cancers will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
LM-108 (a monoclonal antibody that clears tumor-infiltrating regulatory T cells), penpulimab (a PD-1 inhibitor), oxaliplatin, and capecitabine
What this could lead to
If successful, this combination could offer a new treatment option to shrink or slow advanced solid tumors.
What could go wrong
This is an early-phase trial with a small number of participants, so the treatment may not work or could cause significant side effects. Results may not apply to all cancer types.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Anhui Provincial Cancer Hospital
NOT_YET_RECRUITINGHefei, Anhui, 230031, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Hospital of Shandong First Medical University
NOT_YET_RECRUITINGJinan, Shandong, 264000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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First Hospital of Shangxi Medical University
NOT_YET_RECRUITINGTaiyuan, Shangxi, 030001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cancer Center
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian Cancer Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350014, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gansu Wuwei Tumour Hospital
NOT_YET_RECRUITINGWuwei, Gansu, 733099, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITINGNanning, Guangxi, 530021, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Harbin Medical University Cancer Hospital
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150040, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hubei Cancer Hospital
NOT_YET_RECRUITINGWuhan, Hubei, 430079, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Inner Mongolia Hospital of Peking University Cancer Hospita
NOT_YET_RECRUITINGHohhot, Inner Mongolia, 010000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jiangsu Provincial People's Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Jilin Cancer Hospital
NOT_YET_RECRUITINGChangchun, Jilin, 130000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NanJing Drum Tower Hospital
NOT_YET_RECRUITINGNanjing, Jiangsu, 210000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nanyang Second General Hospital
NOT_YET_RECRUITINGNanyang, Henan, 473012, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Peking University Shenzhen Hospita
NOT_YET_RECRUITINGShenzhen, Guangdong, 518000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ping mei shen ma Medical Group General Hospital
RECRUITINGPingdingshan, Henan, 467000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Renji Hospital, Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanxi Cancer Hospital
NOT_YET_RECRUITINGTaiyuan, Shanxi, 030000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sichuan Cancer Hospita
NOT_YET_RECRUITINGChengdu, Sichuan, 610042, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tangshan People's Hospital
NOT_YET_RECRUITINGTangshan, Hebei, 063001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, Jiangsu, 215006, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITINGWenzhou, Zhejiang, 325005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Xi'an Jiaotong University Medical College
NOT_YET_RECRUITINGXi'an, Shaanxi, 710000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITINGZhengzhou, Henan, 450002, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Hospital Of China Medical University
NOT_YET_RECRUITINGShenyang, Liaoning, 110000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Hospital of Lanzhou University
NOT_YET_RECRUITINGLanzhou, Gansu, 730030, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Hospital of Anhui Medical University
NOT_YET_RECRUITINGHefei, Anhui, 230601230601, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The second xiangya hospital of central south university
NOT_YET_RECRUITINGChangsha, Hunan, 410011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITINGTianjin, Tianjin Municipality, 300000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Xinjiang Medical University Affiliated Cancer Hospital
NOT_YET_RECRUITINGÜrümqi, Xinjiang, 830054, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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XuZhou Central Hospital
NOT_YET_RECRUITINGXuzhou, Jiangsu, 221000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••