New Immune-Targeting drug combo takes on advanced cancers

NCT ID NCT06825494

Recruiting now Disease control Sponsor: Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called LM-108, which clears certain immune cells from tumors, combined with standard chemotherapy and another immunotherapy. The goal is to see if this mix is safe and can slow or shrink advanced solid tumors. About 194 adults with advanced cancers will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LM-108 (a monoclonal antibody that clears tumor-infiltrating regulatory T cells), penpulimab (a PD-1 inhibitor), oxaliplatin, and capecitabine
What this could lead to: If successful, this combination could offer a new treatment option to shrink or slow advanced solid tumors.
What could go wrong: This is an early-phase trial with a small number of participants, so the treatment may not work or could cause significant side effects. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMOR

Contacts and locations

Locations

Anhui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230031, China
Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Cancer Hospital of Shandong First Medical University
NOT_YET_RECRUITING

Jinan, Shandong, 264000, China
First Hospital of Shangxi Medical University
NOT_YET_RECRUITING

Taiyuan, Shangxi, 030001, China
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian Cancer Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350014, China
Gansu Wuwei Tumour Hospital
NOT_YET_RECRUITING

Wuwei, Gansu, 733099, China
Guangxi Medical University Cancer Hospital
NOT_YET_RECRUITING

Nanning, Guangxi, 530021, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150040, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, 430079, China
Inner Mongolia Hospital of Peking University Cancer Hospita
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010000, China
Jiangsu Provincial People's Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
Jilin Cancer Hospital
NOT_YET_RECRUITING

Changchun, Jilin, 130000, China
NanJing Drum Tower Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210000, China
Nanyang Second General Hospital
NOT_YET_RECRUITING

Nanyang, Henan, 473012, China
Peking University Shenzhen Hospita
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518000, China
Ping mei shen ma Medical Group General Hospital
RECRUITING

Pingdingshan, Henan, 467000, China
Renji Hospital, Shanghai Jiaotong University School of Medicine
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200120, China
Shanxi Cancer Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030000, China
Sichuan Cancer Hospita
NOT_YET_RECRUITING

Chengdu, Sichuan, 610042, China
Tangshan People's Hospital
NOT_YET_RECRUITING

Tangshan, Hebei, 063001, China
The First Affiliated Hospital of Soochow University
NOT_YET_RECRUITING

Suzhou, Jiangsu, 215006, China
The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325005, China
The First Affiliated Hospital of Xi'an Jiaotong University Medical College
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710000, China
The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450002, China
The First Hospital Of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110000, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730030, China
The Second Hospital of Anhui Medical University
NOT_YET_RECRUITING

Hefei, Anhui, 230601230601, China
The second xiangya hospital of central south university
NOT_YET_RECRUITING

Changsha, Hunan, 410011, China
Tianjin Medical University Cancer Institute & Hospital
NOT_YET_RECRUITING

Tianjin, Tianjin Municipality, 300000, China
Xinjiang Medical University Affiliated Cancer Hospital
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830054, China
XuZhou Central Hospital
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221000, China

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