New drug combo tested to tame dangerous liver pressure
NCT ID NCT05282121
Summary
This study tested if a new drug called Avenciguat, taken alone or with an existing diabetes drug (empagliflozin), could reduce high blood pressure in the main vein leading to the liver. It involved 90 adults with liver cirrhosis from hepatitis B, hepatitis C, or fatty liver disease (NASH). Participants took the pills for 8 weeks, and doctors measured the pressure in their liver veins before and after to see if it worked.
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Contacts and locations
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Locations
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AKH - Medical University of Vienna
Vienna, 1090, Austria
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American Research Corporation
San Antonio, Texas, 78215, United States
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Amsterdam UMC, location VUMC
Amsterdam, 1105 AZ, Netherlands
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Azienda Ospedaliera Policlinico di Modena
Modena, 41124, Italy
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Beijing Friendship Hospital
Beijing, 100050, China
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California Liver Research Institute
Pasadena, California, 91105, United States
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Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, H2X 0A9, Canada
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Edegem - UNIV UZ Antwerpen
Edegem, 2650, Belgium
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Floridian Clinical Research-Miami Lakes-68368
Miami Lakes, Florida, 33016, United States
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HOP Beaujon
Clichy, 92118, France
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HOP Rangueil
Toulouse, 31059, France
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Hospital Britanico de Buenos Aires
CABA, 1280AEB, Argentina
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Hospital Italiano de Buenos Aires
CABA, C1199ABB, Argentina
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Hospital Ramón y Cajal
Madrid, 28034, Spain
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Hospital Vall d'Hebron
Barcelona, 08035, Spain
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Hvidovre Hospital
Hvidovre, 2650, Denmark
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Inland Empire Clinical Trials, LLC
Rialto, California, 92377, United States
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Medizinische Hochschule Hannover
Hanover, 30625, Germany
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NanFang Hosptial
Guangzhou, 510515, China
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National Hospital Organization Yokohama Medical Center
Kanagawa, Yokohama, 245-8575, Japan
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Osaka Metropolitan University Hospital
Osaka, Osaka, 545-8586, Japan
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Ospedale Civile di Baggiovara
Baggiovara (MO), 41126, Italy
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Policlinico "Paolo Giaccone"
Palermo, 90127, Italy
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Rambam Medical Center
Haifa, 31096, Israel
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Regional Institute of Gastroenterology Hepatology "Prof. Dr. O. Fodor"
Cluj-Napoca, 400000, Romania
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Singapore General Hospital
Singapore, 169608, Singapore
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The Affiliated Hospital of Hangzhou Normal University
Hangzhou, 310015, China
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Universitätsklinikum Münster
Münster, 48149, Germany
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Mainz, 55131, Germany
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Western Galilee Hospital
Nahariya, 2210001, Israel
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Zhongshan Hospital Affiliated to Fudan University
Shanghai, 200032, China
Conditions
Explore the condition pages connected to this study.