Major trial tests new hope for tough liver cancers
NCT ID NCT03713593
Summary
This large, completed Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to the standard drug lenvatinib works better for adults with advanced liver cancer. The main goal was to see if the combination helps patients live longer without their cancer getting worse, compared to taking lenvatinib alone. Nearly 800 people participated to find the most effective first treatment for this serious condition.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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900 Hospital of the Joint ( Site 0091)
Fuzhou, Fujian, 350025, China
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Abdurrahman Yurtaslan Onkoloji Hastanesi ( Site 0551)
Ankara, 06200, Turkey (Türkiye)
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Adana Sehir Hastanesi ( Site 0549)
Adana, 01250, Turkey (Türkiye)
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Administradora Country SA - Clinica del Country ( Site 0146)
Bogotá, Bogota D.C., 110221, Colombia
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Advent Health ( Site 0595)
Orlando, Florida, 32804, United States
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Affiliated Tumor Hospital of Xinjiang Medical University ( Site 0109)
Ürümqi, Xinjiang, 830001, China
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Aichi Cancer Center Hospital ( Site 0316)
Nagoya, Aichi-ken, 464-8681, Japan
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Akdeniz Universitesi Tip Fakultesi ( Site 0548)
Antalya, 07070, Turkey (Türkiye)
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Ars Medical Sp. z o.o. ( Site 0433)
Piła, 64-920, Poland
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Asan Medical Center ( Site 0460)
Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
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Auckland City Hospital ( Site 0376)
Auckland, 1023, New Zealand
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Az Osp Univ Policlin Paolo Giaccone ( Site 0284)
Palermo, 90127, Italy
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Azienda Ospedaliero-Univers. Pisana Ospedale S. Chiara ( Site 0291)
Pisa, 56126, Italy
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BC Cancer-Vancouver Center ( Site 0056)
Vancouver, British Columbia, V5Z 4E6, Canada
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Beijing Cancer Hospital ( Site 0088)
Beijing, Beijing Municipality, 100142, China
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Beth Israel Deaconess Medical Center ( Site 0716)
Boston, Massachusetts, 02215, United States
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Bezmi Alem Universitesi Tıp Fakultesi ( Site 0547)
Istanbul, 34093, Turkey (Türkiye)
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Biomelab S A S ( Site 0145)
Barranquilla, Atlántico, 080002, Colombia
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CHRU de Lille - Hopital Claude Huriez ( Site 0159)
Lille, 59037, France
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CHU Henri Mondor ( Site 0162)
Créteil, 94000, France
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CHU de Nancy Hopital Brabois Adultes ( Site 0164)
Vandœuvre-lès-Nancy, 54500, France
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CRYPTEX Investigacion Clinica S.A. de C.V. ( Site 0362)
Mexico City, 06100, Mexico
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Cancer Care Northwest ( Site 0636)
Spokane, Washington, 99218, United States
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Cancer Hospital Chinese Academy of Medical Sciences ( Site 0100)
Beijing, Beijing Municipality, 100021, China
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Central Texas Veterans Healthcare System ( Site 0617)
Temple, Texas, 76504, United States
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Centre Eugene Marquis ( Site 0158)
Rennes, 35042, France
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Centre Hospitalier Regional du Orleans ( Site 0169)
Orléans, 45100, France
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Centro Medico Imbanaco de Cali S.A ( Site 0139)
Cali, Valle del Cauca Department, 760042, Colombia
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Centro de Investigacion Medica Aguascalientes ( Site 0355)
Aguascalientes, 20116, Mexico
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Centro di Riferimento Oncologico de Aviano Istituto Nazionale Tumori ( Site 0292)
Aviano, 33081, Italy
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Chang Gung Medical Foundation. Linkou ( Site 0525)
Taoyuan District, 333, Taiwan
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Chiang Mai University Maharaj Nakorn Chiang Mai Hospital ( Site 0211)
Chiang Mai, 50200, Thailand
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Chiba University Hospital ( Site 0305)
Chiba, 260-8677, Japan
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China Medical University Hospital ( Site 0527)
Taichung, 404, Taiwan
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Christchurch Hospital ( Site 0377)
Christchurch, 8011, New Zealand
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City Clinical Oncology Center ( Site 0446)
Saint Petersburg, Sankt-Peterburg, 198255, Russia
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City of Hope Comprehensive Cancer Center ( Site 0587)
Duarte, California, 91010, United States
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Clinica Universidad Catolica del Maule ( Site 0065)
Talca, Maule Region, 3465584, Chile
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Complejo Hospitalario Universitario de Santiago ( Site 0506)
Santiago de Compostela, 15706, Spain
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Eastern Regional Medical Center, Inc. ( Site 0626)
Philadelphia, Pennsylvania, 19124, United States
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Emory University Winship Cancer Institute ( Site 0639)
Atlanta, Georgia, 30322, United States
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Erzurum Ataturk University Faculty of Medicine ( Site 0546)
Erzurum, 25240, Turkey (Türkiye)
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First Affiliated Hospital of Anhui Medical University ( Site 0095)
Hefei, Anhui, 230088, China
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First Moscow State Medical University n.a. I.M.Sechenov ( Site 0453)
Moscow, Moscow, 119881, Russia
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Fondazione Salvatore Maugeri IRCCS. ( Site 0290)
Pavia, 27100, Italy
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Fudan University Shanghai Cancer Center ( Site 0086)
Shanghai, Shanghai Municipality, 200032, China
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Fundacion Arturo Lopez Perez ( Site 0064)
Santiago, Santiago Metropolitan, 7500921, Chile
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Fundacion Centro de Investigacion Clinica CIC ( Site 0141)
Medellín, Antioquia, 050021, Colombia
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Fundacion Valle del Lili ( Site 0140)
Cali, Valle del Cauca Department, 760032, Colombia
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Georgetown University ( Site 0594)
Washington D.C., District of Columbia, 20007, United States
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Guangdong General Hospital ( Site 0092)
Guangzhou, Guangdong, 510080, China
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Hacettepe Uni. Tip Fakultesi ( Site 0553)
Ankara, 06100, Turkey (Türkiye)
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Harbin Medical University Cancer Hospital ( Site 0089)
Harbin, Heilongjiang, 610000, China
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Hiroshima University Hospital ( Site 0320)
Hiroshima, 734-8551, Japan
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Hokkaido P.W.F.A.C Sapporo-Kosei General Hospital ( Site 0304)
Sapporo, Hokkaido, 060-0033, Japan
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Hopital Beaujon ( Site 0160)
Clichy, 92110, France
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Hopital Saint Joseph ( Site 0166)
Marseille, 13285, France
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Hopital de la Croix Rousse ( Site 0157)
Lyon, 69004, France
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Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0365)
Guadalajara, Jalisco, 44280, Mexico
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Hospital General Universitario Gregorio Maranon ( Site 0504)
Madrid, 28007, Spain
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Hospital General de Medellin Luz Castro de Gutierrez ( Site 0137)
Medellín, Antioquia, 500515, Colombia
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Hospital Pablo Tobon Uribe ( Site 0144)
Medellín, Antioquia, 050034, Colombia
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Hospital Universitari Vall d Hebron ( Site 0508)
Barcelona, Barcelona [Barcelona], 08035, Spain
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Hospital Universitario La Paz ( Site 0510)
Madrid, 28046, Spain
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Hospital Universitario Puerta de Hierro ( Site 0513)
Majadahonda, Madrid, 28222, Spain
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Hospital Universitario Ramon y Cajal ( Site 0514)
Madrid, 28034, Spain
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Hospital Universitario Virgen del Rocio ( Site 0509)
Seville, 41013, Spain
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Hospital Universitario y Politecnico La Fe de Valencia ( Site 0505)
Valencia, 46026, Spain
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Hunan Cancer Hospital ( Site 0094)
Changsha, Hunan, 410006, China
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ID Clinic ( Site 0431)
Mysłowice, 41-400, Poland
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Icahn School of Medicine at Mount Sinai ( Site 0611)
New York, New York, 10029, United States
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Inonu Universitesi Medical Fakultesi ( Site 0545)
Malatya, 44280, Turkey (Türkiye)
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Institut Sainte Catherine ( Site 0167)
Avignon, 84918, France
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Instituto Clinico Oncologico del Sur ( Site 0067)
Temuco, 4810469, Chile
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Instituto Nacional de Cancerologia E.S.E ( Site 0142)
Bogotá, Bogota D.C., 111511, Colombia
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 0363)
Mexico City, Mexico City, 14080, Mexico
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Istituto Oncologico Veneto ( Site 0287)
Padua, 35128, Italy
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Kagawa Prefectural Central Hospital ( Site 0325)
Takamatsu, Kagawa-ken, 760-8557, Japan
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Kagawa University Hospital ( Site 0324)
Kita-gun, Kagawa-ken, 761-0793, Japan
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Kanagawa Cancer Center ( Site 0314)
Yokohama, Kanagawa, 241-8515, Japan
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Kanazawa University Hospital ( Site 0315)
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 0529)
Kaoshiung, 807, Taiwan
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Kindai University Hospital ( Site 0319)
Sayama, Osaka, 589-8511, Japan
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Kings College Hospital NHS Foundation Trust ( Site 0565)
London, London, City of, SE5 9RS, United Kingdom
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Klinikum der Universitaet Aachen - RWTH ( Site 0185)
Aachen, 52074, Germany
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Krasnoyarsk Regional Clinical Oncological Dispensary ( Site 0450)
Krasnoyarsk, 660133, Russia
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Kurume University Hospital ( Site 0322)
Kurume, Fukuoka, 830-0011, Japan
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Kyorin University Hospital ( Site 0309)
Mitaka, Tokyo, 181-8611, Japan
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Liverpool Hospital. ( Site 0002)
Liverpool, 2170, Australia
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London Health Sciences Centre ( Site 0053)
London, Ontario, N6A 5A5, Canada
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MTZ Clinical Research Sp. z o. o. ( Site 0427)
Warsaw, 02-106, Poland
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Massachusetts General Hospital ( Site 0603)
Boston, Massachusetts, 02114, United States
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Mater Misericordiae University Hospital ( Site 0241)
Dublin, D07 R2WY, Ireland
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McGill University Health Centre ( Site 0052)
Montreal, Quebec, H4A 3J1, Canada
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Medical Care and Research S.A. de C.V. ( Site 0359)
Mérida, 97070, Mexico
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Monash Health-Monash Medical Centre ( Site 0004)
Clayton, Victoria, 3168, Australia
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Musashino Red Cross Hospital ( Site 0310)
Musashino, Tokyo, 180-8610, Japan
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N.N. Blokhin NMRCO ( Site 0439)
Moscow, Moscow, 115478, Russia
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Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0418)
Warsaw, 02-034, Poland
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National Cancer Center Hospital ( Site 0307)
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East ( Site 0306)
Kashiwa, Chiba, 277-8577, Japan
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National Cheng Kung University Hospital ( Site 0528)
Tainan, 70457, Taiwan
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National Hospital Organization Kyushu Medical Center ( Site 0321)
Fukuoka, 810-8563, Japan
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National Taiwan University Hospital ( Site 0523)
Taipei, 100, Taiwan
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Necmettin Erbakan Universitesi Meram Tip Fakultesi ( Site 0550)
Konya, 42080, Turkey (Türkiye)
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Nottingham University Hospitals NHS Trust ( Site 0569)
Nottingham, NG5 1PB, United Kingdom
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Oaxaca Site Management Organization S.C. ( Site 0366)
Oaxaca City, 68000, Mexico
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Oregon Health & Science University ( Site 0645)
Portland, Oregon, 97239, United States
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Osaka Red Cross Hospital ( Site 0317)
Osaka, 543-8555, Japan
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Ospedale Sacro Cuore - Don Calabria ( Site 0289)
Negrar, VR, 37024, Italy
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Otto-Von-Guericke-Universitaet Magdeburg ( Site 0182)
Magdeburg, 39120, Germany
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Pacific Hematology Oncology Associates ( Site 0588)
San Francisco, California, 94115, United States
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Policlinico S. Orsola-Malpighi ( Site 0286)
Bologna, 40138, Italy
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Policlinico Universitario Campus Biomedico ( Site 0288)
Roma, 00128, Italy
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Pontificia Universidad Catolica de Chile ( Site 0070)
Santiago, Santiago Metropolitan, 8330024, Chile
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Princess Alexandra Hospital ( Site 0007)
Wooloongabba, Queensland, 4102, Australia
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Princess Margaret Cancer Centre ( Site 0050)
Toronto, Ontario, M5G 2M9, Canada
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Pyatigorsk Oncology Dispensary ( Site 0441)
Pyatigorsk, 357502, Russia
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Railway Hospital of OJSC ( Site 0447)
Saint Petersburg, Sankt-Peterburg, 195271, Russia
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Royal Free London NHS Foundation Trust ( Site 0567)
London, London, City of, NW3 2QG, United Kingdom
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Royal Prince Alfred Hospital ( Site 0001)
Camperdown, New South Wales, 2050, Australia
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Saga-Ken Medical Centre Koseikan ( Site 0323)
Saga, 840-8571, Japan
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Samsung Medical Center ( Site 0461)
Seoul, 06351, South Korea
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Scripps Health ( Site 0644)
La Jolla, California, 92037, United States
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Seoul National University Bundang Hospital ( Site 0464)
Seongnam-si, Kyonggi-do, 13620, South Korea
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Seoul National University Hospital ( Site 0462)
Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
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Sir Run Run Shaw Hospital ( Site 0110)
Hangzhou, Zhejiang, 310016, China
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Siriraj Hospital. Mahidol Univerisity ( Site 0213)
Bangkok Noi, Bangkok, 10700, Thailand
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Songklanagarind Hospital ( Site 0214)
Hat Yai, Changwat Songkhla, 90110, Thailand
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Southern Medical University Nanfang Hospital ( Site 0102)
Guangzhou, Guangdong, 510515, China
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St Vincents Hospital Melbourne ( Site 0003)
Fitzroy, Victoria, 3065, Australia
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St Vincents University Hospital ( Site 0242)
Dublin, D04 T6F4, Ireland
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Stony Brook University Medical Center - Cancer Center ( Site 0612)
Stony Brook, New York, 11794, United States
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Sunnybrook Research Institute ( Site 0055)
Toronto, Ontario, M4N 3M5, Canada
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Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 0421)
Koszalin, West Pomeranian Voivodeship, 75-581, Poland
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Taichung Veterans General Hospital ( Site 0526)
Taichung, 407, Taiwan
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Taipei Veterans General Hospital ( Site 0524)
Taipei, 112, Taiwan
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Tampa General Medical Group ( Site 0629)
Tampa, Florida, 33606, United States
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The 81st Hospital of PLA ( Site 0085)
Nanjing, Jiangsu, 210031, China
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The Beatson West of Scotland Cancer Centre ( Site 0566)
Glasgow, G12 0YN, United Kingdom
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The Christie NHS Foundation Trust ( Site 0575)
Manchester, M20 4BX, United Kingdom
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The Clatterbridge Cancer Centre NHS Foundation Trust ( Site 0573)
Birkenhead, CH63 4JY, United Kingdom
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The First Affiliated Hospital of Xi an Jiaotong University ( Site 0090)
Xi’an, Shanxi, 710061, China
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The First Affiliated Hospital of Zhejiang University ( Site 0097)
Hangzhou, Zhejiang, 310003, China
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The Third Xiangya Hospital of Central South University ( Site 0093)
Changsha, Hunan, 410013, China
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The University of Arizona Cancer Center - North Campus ( Site 0621)
Tucson, Arizona, 85721, United States
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The University of Tokyo Hospital ( Site 0308)
Tokyo, 113-8655, Japan
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Toranomon Hospital ( Site 0311)
Tokyo, 105-8470, Japan
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Toranomon Hospital Kajigaya ( Site 0312)
Kawasaki, Kanagawa, 213-8587, Japan
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Trakya Universitesi Tip Fakultesi ( Site 0544)
Edirne, 22030, Turkey (Türkiye)
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UCLA ( Site 0589)
Santa Monica, California, 90404, United States
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Unidad Medica Oncologica ( Site 0369)
Puebla City, 72530, Mexico
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Universitaetsklinik Koeln ( Site 0189)
Cologne, 50937, Germany
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Universitaetsklinikum Carl Gustav Carus der TU Dresden ( Site 0178)
Dresden, 01307, Germany
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Universitaetsklinikum Essen ( Site 0188)
Essen, 45147, Germany
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Universitaetsklinikum Frankfurt ( Site 0180)
Frankfurt am Main, 60596, Germany
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Universitaetsklinikum Hamburg-Eppendorf ( Site 0184)
Hamburg, 20246, Germany
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Universitaetsklinikum Leipzig ( Site 0187)
Leipzig, 04103, Germany
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Universitaetsklinikum Tuebingen ( Site 0179)
Tübingen, 72076, Germany
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Universitaetsklinikum Wuerzburg ( Site 0186)
Würzburg, 97080, Germany
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University of Kansas Cancer Center ( Site 0600)
Westwood, Kansas, 66205, United States
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University of Miami, Sylvester Comprehensive Cancer Center ( Site 0596)
Miami, Florida, 33136, United States
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University of Oklahoma Health Science Center ( Site 0625)
Oklahoma City, Oklahoma, 73104, United States
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University of Rochester ( Site 0613)
Rochester, New York, 14642, United States
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Wakayama Medical University Hospital ( Site 0318)
Wakayama, 641-8510, Japan
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West China Hospital of Sichuan University ( Site 0087)
Chengdu, Sichuan, 610000, China
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Wojewodzki Szpital Specjalistyczny nr 4 w Bytomiu ( Site 0419)
Bytom, Silesian Voivodeship, 41-902, Poland
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Wuhan Union hospital Cancer Center ( Site 0105)
Wuhan, Hubei, 430022, China
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Yokohama City University Medical Center ( Site 0313)
Yokohama, Kanagawa, 232-0024, Japan
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Yonsei University Severance Hospital ( Site 0463)
Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
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Zhejiang Cancer Hospital ( Site 0101)
Hangzhou, Zhejiang, 310022, China
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Zhongshan Hospital Fudan University ( Site 0096)
Shanghai, 200032, China
Conditions
Explore the condition pages connected to this study.