Can sound waves tame the autonomic nervous system?

NCT ID NCT05834829

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether low-intensity focused ultrasound (LIFU) aimed at specific brain regions can influence how the body controls automatic functions like heart rate and blood pressure. Researchers will apply LIFU or a sham (fake) version to 80 volunteers and measure changes during a cold-water hand immersion test. The goal is to understand if this non-invasive technique can alter autonomic control, which could one day help people with autonomic dysfunction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Low-intensity focused ultrasound (LIFU) device

What this could lead to

If successful, this could point toward a non-invasive brain stimulation treatment for autonomic dysfunction.

What could go wrong

This is a small, early-stage study focused on measuring physiological responses, not treating disease. The intervention is experimental and may not produce meaningful clinical benefits.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

primary dysautonomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fralin Biomedical Research Institute at VTC

    Roanoke, Virginia, 24016, United States