New drug duo aims to knock out stubborn leukemia

NCT ID NCT03504644

Ongoing Disease control Sponsor: ECOG-ACRIN Cancer Research Group Source: ClinicalTrials.gov ↗

Summary

This study is testing a combination of two drugs, venetoclax and vincristine, for adults with a fast-growing blood cancer called acute lymphoblastic leukemia (ALL) that has come back or hasn't responded to previous treatments. The goal is to see if using these drugs together is safe, find the best dose, and determine if they can help put the cancer into remission. Researchers hope this combination will work better than using the chemotherapy drug alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
CARTI Cancer Center

Little Rock, Arkansas, 72205, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Center-Metro Medical Center Bayamon

Bayamón, 00959-5060, Puerto Rico
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Delbert Day Cancer Institute at PCRMC

Rolla, Missouri, 65401, United States
Doctors Cancer Center

Manatí, 00674, Puerto Rico
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Good Samaritan Regional Health Center

Mount Vernon, Illinois, 62864, United States
HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, 62269, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Lake Regional Hospital

Osage Beach, Missouri, 65065, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Loyola Center for Health at Burr Ridge

Burr Ridge, Illinois, 60527, United States
Loyola Medicine Homer Glen

Homer Glen, Illinois, 60491, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, Illinois, 60160, United States
Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Medical Center

Springfield, Illinois, 62781, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Monmouth Medical Center

Long Branch, New Jersey, 07740, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwestern University

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
PROncology

San Juan, 00927, Puerto Rico
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Puerto Rico Hematology Oncology Group

Bayamón, 00961, Puerto Rico
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
Saint Anthony's Health

Alton, Illinois, 62002, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Louis Cancer and Breast Institute-Ballwin

Ballwin, Missouri, 63011, United States
Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri, 63109, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Mary's Hospital

Centralia, Illinois, 62801, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
San Juan City Hospital

San Juan, 00936, Puerto Rico
San Juan Community Oncology Group

San Juan, 00917, Puerto Rico
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Southeast Cancer Center

Cape Girardeau, Missouri, 63703, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University of Florida Health Science Center - Jacksonville

Jacksonville, Florida, 32209, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Yale University

New Haven, Connecticut, 06520, United States

Conditions

Explore the condition pages connected to this study.

RECURRENT ADULT LYMPHOBLASTIC LYMPHOMA RECURRENT B ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT B LYMPHOBLASTIC LYMPHOMA RECURRENT T ACUTE LYMPHOBLASTIC LEUKEMIA RECURRENT T LYMPHOBLASTIC LYMPHOMA REFRACTORY B ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY B LYMPHOBLASTIC LYMPHOMA REFRACTORY T ACUTE LYMPHOBLASTIC LEUKEMIA REFRACTORY T LYMPHOBLASTIC LYMPHOMA