Could a common fertility drug improve miscarriage care?
NCT ID NCT07160855
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether taking letrozole before misoprostol helps women with missed miscarriage pass pregnancy tissue more completely than misoprostol alone. Ninety-two women in early pregnancy (up to 13 weeks) will be randomly assigned to receive either letrozole or a placebo for three days, followed by misoprostol. The main goal is to see if the combination leads to a complete abortion within 24 hours without needing surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- letrozole and misoprostol
- What this could lead to
- If it works, this could offer a more effective medication option for managing missed miscarriage, reducing the need for surgical procedures.
- What could go wrong
- This is a small, early-phase trial with only 92 participants. Adding letrozole may not improve outcomes and could cause additional side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Nishtar Medical University and Hospital
RECRUITINGMultan, Punjab Province, 60000, Pakistan
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