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Could a common breast cancer drug keep ovarian cancer at bay?

NCT ID NCT04111978

Recruiting now Disease control Sponsor: Swiss GO Trial Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial is testing whether adding letrozole (a hormone-blocking drug) to standard maintenance therapy can delay cancer recurrence in people with estrogen-receptor-positive ovarian cancer. About 540 participants who have completed initial surgery and chemotherapy will receive either letrozole or a placebo. The study aims to see if letrozole improves the time before the cancer comes back.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Letrozole (Femara)
What this could lead to
If it works, this could provide a new maintenance option to delay ovarian cancer recurrence after standard treatment.
What could go wrong
This is a Phase 3 trial, but it is still recruiting and results are not yet known. Letrozole may not improve progression-free survival compared to placebo, and side effects like bone thinning or hot flashes are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma fallopian tube neoplasm ovarian endometrioid adenocarcinoma ovarian epithelial tumor ovarian serous adenocarcinoma peritoneal carcinoma peritoneal neoplasm primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FALLOPIAN TUBE NEOPLASMS HIGH-GRADE SEROUS OVARIAN CARCINOMA (HGSOC) LOW-GRADE SEROUS OVARIAN CARCINOMA (LGSOC) OVARIAN ENDOMETRIOID CARCINOMA OVARIAN NEOPLASM EPITHELIAL PERITONEAL NEOPLASMS

Contacts and locations

Locations

  • AMO Wolfsburg / AMO MVZ GmbH

    RECRUITING

    Wolfsburg, 38440, Germany

  • Agaplesion Diakonieklinikum Hamburg

    RECRUITING

    Hamburg, 20259, Germany

  • Basel Claraspital AG

    RECRUITING

    Basel, 4002, Switzerland

  • Centre Hospitalier du Valais Romand

    RECRUITING

    Sion, Valais, Switzerland

  • Charité - Universitätsmedizin Berlin Campus Virchow Klinikum

    RECRUITING

    Berlin, 13353, Germany

  • Donauisar Klinikum

    RECRUITING

    Deggendorf, 94469, Germany

  • Evangelische Kliniken Essen Mitte GmbH

    RECRUITING

    Essen, 45136, Germany

  • Evangelisches Krankenhaus Düsseldorf

    RECRUITING

    Düsseldorf, 40217, Germany

  • Frauenklinik Spital Grabs

    RECRUITING

    Grabs, 9472, Switzerland

  • Gynäkologisch-Onkologische Gemeinschaftspraxis Dres. med. C.Uleer/J.Y.Pourfard

    RECRUITING

    Hildesheim, 31134, Germany

  • Helios Dr. Horst Schmidt Kliniken Wiesbaden

    RECRUITING

    Wiesbaden, 65199, Germany

  • Helios Universitätsklinikum Wuppertal

    RECRUITING

    Wuppertal, 42117, Germany

  • Hôpitaux Universitaires de Genève

    RECRUITING

    Geneva, 1205, Switzerland

  • Kantonspital Graubünden (KSGR),

    RECRUITING

    Chur, 7000, Switzerland

  • Kantonsspital Aarau AG

    RECRUITING

    Aarau, Canton of Aargau, 5001, Switzerland

  • Kantonsspital Baden AG

    RECRUITING

    Baden, 5404, Switzerland

  • Kantonsspital Baselland

    RECRUITING

    Liestal, 4410, Switzerland

  • Kantonsspital Frauenfeld

    RECRUITING

    Frauenfeld, 8501, Switzerland

  • Kantonsspital Münsterlingen

    RECRUITING

    Münsterlingen, 8596, Switzerland

  • Kantonsspital St. Gallen

    RECRUITING

    Sankt Gallen, 9007, Switzerland

  • Kantonsspital Winterthur

    RECRUITING

    Winterthur, 8401, Switzerland

  • Klinik Hietzing Wien

    RECRUITING

    Vienna, 1130, Austria

  • Klinik für Onkologie und Hämatologie Hirslanden Zürich AG

    RECRUITING

    Zurich, 8032, Switzerland

  • Klinikum Esslingen

    RECRUITING

    Esslingen am Neckar, 73730, Germany

  • Klinikum Konstanz

    RECRUITING

    Konstanz, 78464, Germany

  • Krankenhaus der Barmherzigen Brüder Graz

    RECRUITING

    Graz, 8020, Austria

  • Landeskrankenhaus Hochsteiermark Leoben

    RECRUITING

    Leoben, 8700, Austria

  • Leopoldina Krankenhaus der Stadt Schweinfurt

    RECRUITING

    Schweinfurt, 97422, Germany

  • Luzerner Kantonsspital

    RECRUITING

    Lucerne, 6000, Switzerland

  • Medizinische Universität Graz

    RECRUITING

    Graz, 8036, Austria

  • Medizinische Universität Innsbruck

    RECRUITING

    Innsbruck, 6020, Austria

  • Medizinische Universität Wien

    RECRUITING

    Vienna, 1090, Austria

  • Oncology Institute of Southern Switzerland (IOSI)-Ente Ospedaliero Cantonale (EOC)

    RECRUITING

    Bellinzona, Canton Ticino, 6500, Switzerland

  • Ordensklinikum Linz Barmherzige Schwestern

    RECRUITING

    Linz, 4010, Austria

  • Praxis im Frauenzentrum Lindenhofspital

    RECRUITING

    Bern, 3012, Switzerland

  • SL Klinikum Rosenheim

    ACTIVE_NOT_RECRUITING

    Rosenheim, 83022, Germany

  • St. Elisabeth-Krankenhaus

    RECRUITING

    Cologne, 50935, Germany

  • Stadtspital Triemli

    RECRUITING

    Zurich, 8063, Switzerland

  • Studienzentrum Onkologie Ravensburg

    RECRUITING

    Ravensburg, 88212, Germany

  • The University Medical Center Hamburg-Eppendorf

    RECRUITING

    Hamburg, 20251, Germany

  • Tumorzentrum Hirslanden Klinik St. Anna

    RECRUITING

    Lucerne, 6006, Switzerland

  • Unispital Zürich

    RECRUITING

    Zurich, 8091, Switzerland

  • University Hospital Freiburg

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • University Hospital Münster

    RECRUITING

    Münster, 48149, Germany

  • Universitätsklinik Ulm

    RECRUITING

    Ulm, 89075, Germany

  • Universitätsklinik für Medizinische Onkologie, Inselspital

    RECRUITING

    Bern, 3010, Switzerland

  • Universitätsklinikum Carl Gustav Carus Dresden

    ACTIVE_NOT_RECRUITING

    Dresden, 01307, Germany

  • Universitätsklinikum Düsseldorf

    RECRUITING

    Düsseldorf, 40225, Germany

  • Universitätsklinikum Mannheim

    RECRUITING

    Mannheim, 68167, Germany

  • Universitätsklinikum Salzburg

    RECRUITING

    Salzburg, 5020, Austria

  • Universitätsmedizin Mainz

    RECRUITING

    Mainz, 55131, Germany

  • Universitätsspital Basel

    RECRUITING

    Basel, Canton of Basel-City, 4031, Switzerland

  • Universitätsspital Waadt/ CHUV

    RECRUITING

    Lausanne, 1011, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.