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Radiation boost may Re-Sensitize ovarian cancer to PARP inhibitors

NCT ID NCT05990192

Recruiting now Disease control Sponsor: Institute of Cancer Research, United Kingdom Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This phase 2 trial investigates whether adding stereotactic body radiotherapy (SBRT) to the PARP inhibitor niraparib can improve control of ovarian cancer that has spread to a limited number of new spots after prior PARP inhibitor therapy. Participants will receive SBRT alone or SBRT followed by niraparib. The study aims to see if this combination delays further cancer growth and is feasible for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
niraparib (Zejula) and stereotactic body radiotherapy (SBRT)
What this could lead to
If successful, this approach could offer a new way to manage ovarian cancer that has spread to a few spots, potentially delaying the need for stronger chemotherapy.
What could go wrong
This is a small, early-phase trial, so results may not apply to all patients. SBRT can cause side effects like fatigue or pain at the treated site, and niraparib may cause nausea or low blood counts.

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Conditions

The condition(s) this trial relates to.

fallopian tube carcinoma ovarian cancer primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER RECURRENT

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Leicester Royal Infirmary

    RECRUITING

    Leicester, Leicester, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • St James's University Hospital

    RECRUITING

    Leeds, Leeds, LS9 7TF, United Kingdom

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, Manchester, M20 4BX, United Kingdom

    Contact

    Contact Email: •••••@•••••

    Contact

  • The Royal Marsden NHS Foundation Trust

    RECRUITING

    Sutton, Surrey, SM2 5PT, United Kingdom

    Contact

    Contact Email: •••••@•••••

    Contact

  • The Royal Marsden NHS Foundation Trust

    RECRUITING

    London, SW3 6JJ, United Kingdom

    Contact

    Contact Email: •••••@•••••

    Contact

  • University College London Hospitals

    RECRUITING

    London, UK, NW1 2PG, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Western General Hospital

    RECRUITING

    Edinburgh, Scotland, EH4 2XU, United Kingdom

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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