Leg supplement shows promise for heavy, tired legs

NCT ID NCT07185386

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a dietary supplement containing diosmin, hesperidin, bromelain, and ruscus aculeatus in 80 adults with early signs of chronic venous disease, like heavy or swollen legs. Participants took the supplement for 12 weeks, and researchers measured changes in quality of life using a standard questionnaire. The goal was to see if the supplement could ease symptoms and improve daily comfort.

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Conditions

The condition(s) this trial relates to.

chronic venous insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • AOU Policlinico Sant'Orsola Malpighi

    Bologna, BO, 40138, Italy

  • IRCCS San Raffaele Pisana

    Roma, Roma, 00163, Italy

  • Università degli Studi Magna Graecia

    Catanzaro, CZ, 88100, Italy

  • Vi.Gi. Centro Polispecialistico

    Vibo Valentia, VV, 89900, Italy