Promising Alzheimer's drug slows memory loss in major trial

NCT ID NCT01767311

Completed Disease control Sponsor: Eisai Inc. Source: ClinicalTrials.gov ↗

First seen Mar 10, 2026 · Last updated May 15, 2026 · Updated 12 times

Summary

This study tested a drug called lecanemab (BAN2401) in 856 people with early Alzheimer's disease (mild memory problems or mild dementia). The goal was to see if the drug could slow down worsening of memory and thinking skills compared to a placebo. Participants received different doses of the drug or a placebo for 18 months, and then could continue on the drug for up to 5 more years. The results helped show that lecanemab can slow cognitive decline, leading to its approval by the FDA. However, the drug does not cure Alzheimer's, and people taking it need ongoing treatment.

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Contacts and locations

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Locations

Eisai Trial Site #1

Otake-shi, Hiroshima, Japan
Eisai Trial Site #1

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #1

Kobe, Hyōgo, Japan
Eisai Trial Site #1

Nishinomiya-shi, Hyōgo, Japan
Eisai Trial Site #1

Kyoto, Kyoto, Japan
Eisai Trial Site #1

Kurashiki-shi, Okayama-ken, Japan
Eisai Trial Site #1

Osaka, Osaka, Japan
Eisai Trial Site #1

Saitama-shi, Saitama, Japan
Eisai Trial Site #1

Itabashi-ku, Tokyo-To, Japan
Eisai Trial Site #1

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #2

Himeji-shi, Hyōgo, Japan
Eisai Trial Site #2

Shinjuku-ku, Tokyo-To, Japan
Eisai Trial Site #3

Himeji-shi, Hyōgo, Japan
Facility #1

Birmingham, Alabama, 35294, United States
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Phoenix, Arizona, 85004, United States
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Tucson, Arizona, 85724, United States
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Carson, California, 90746, United States
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Lomita, California, 90717, United States
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Long Beach, California, 90806, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90024, United States
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Orange, California, United States
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Oxnard, California, 93030, United States
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San Diego, California, 92123, United States
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Denver, Colorado, 80239-3133, United States
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New Haven, Connecticut, 06510, United States
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Atlantis, Florida, 33462, United States
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Boca Raton, Florida, 33431, United States
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Bradenton, Florida, 34205, United States
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Deerfield Beach, Florida, 33064, United States
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Delray Beach, Florida, 33445, United States
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Fort Myers, Florida, 33912, United States
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Hallandale, Florida, 33009, United States
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Hialeah, Florida, 33016, United States
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Lake Worth, Florida, 33449, United States
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Leesburg, Florida, 34748, United States
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Miami, Florida, 33133, United States
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Miami Springs, Florida, 33166, United States
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Naples, Florida, 34102, United States
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Ocala, Florida, 34471, United States
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Orlando, Florida, 32806, United States
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Palm Beach Gardens, Florida, 33410, United States
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St. Petersburg, Florida, 33713, United States
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Sunrise, Florida, 33351, United States
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Tampa, Florida, 33613, United States
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The Villages, Florida, United States
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Atlanta, Georgia, 30329, United States
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Columbus, Georgia, 31909, United States
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Decatur, Georgia, 30033, United States
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Chicago, Illinois, 60640, United States
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Elk Grove Village, Illinois, 60007, United States
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Elkhart, Indiana, 46514, United States
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Indianapolis, Indiana, 46202, United States
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Wichita, Kansas, 67214, United States
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Lexington, Kentucky, 40504, United States
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Boston, Massachusetts, 02115, United States
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Burlington, Massachusetts, 01805, United States
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Newton, Massachusetts, 02459, United States
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Ann Arbor, Michigan, 48105-2945, United States
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East Lansing, Michigan, United States
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Farmington Hills, Michigan, 48334, United States
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Lansing, Michigan, 48824, United States
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West Bloomfield, Michigan, 48322, United States
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St Louis, Missouri, 63118, United States
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Eatontown, New Jersey, 07724, United States
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Toms River, New Jersey, 08755, United States
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Albany, New York, 12206, United States
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Amherst, New York, 14226, United States
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Latham, New York, 12110, United States
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New York, New York, 10016, United States
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Rochester, New York, 14620, United States
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Charlotte, North Carolina, 28211, United States
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Centerville, Ohio, 45459, United States
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Oklahoma City, Oklahoma, 73112, United States
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Portland, Oregon, 97239, United States
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Abington, Pennsylvania, 19001, United States
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Jenkintown, Pennsylvania, 19046, United States
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East Providence, Rhode Island, 02914, United States
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Knoxville, Tennessee, 37920, United States
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Austin, Texas, 78757, United States
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Dallas, Texas, 75214, United States
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Houston, Texas, 77074, United States
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San Antonio, Texas, 78229, United States
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Bennington, Vermont, 05201, United States
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Richmond, Virginia, 23294, United States
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Milwaukee, Wisconsin, 53226, United States
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Kentville, Nova Scotia, Canada
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Kingston, Ontario, Canada
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Ottawa, Ontario, Canada
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Peterborough, Ontario, Canada
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Toronto, Ontario, Canada
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Greenfield Park, Quebec, Canada
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Montreal, Quebec, Canada
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Verdun, Quebec, Canada
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Québec, Canada
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Strasbourg, Bas Rhin, France
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Toulouse, Haute Garonne, France
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Paris, Paris, France
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Bron, France
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Paris, France
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Rennes, France
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Villeurbanne, France
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Gunzburg, Baden-Wurttemberg, Germany
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Karlstadt am Main, Bavaria, Germany
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Hanover, Lower Saxony, Germany
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Mittweida, Saxony, Germany
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Hoppegarten, State of Berlin, Germany
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Berlin, Germany
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Günzburg, Germany
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Hamburg, Germany
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Heidelberg, Germany
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Leipzig, Germany
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Mannheim, Germany
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München, Germany
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Tübingen, Germany
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Brescia, Italy
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Genova, Italy
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Milan, Italy
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Parma, Italy
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Perugia, Italy
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Pisa, Italy
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Roma, Italy
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Amsterdam, Netherlands
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Seongnam-si, Gyeonggi-do, South Korea
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Pusan, Gyeongsangnam-do, South Korea
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Sant Cugat Del Vallés, Barcelona, Spain
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Donostia / San Sebastian, Guipuzcoa, Spain
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Barakaldo, Vizcaya, Spain
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Alicante, Spain
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Barcelona, Spain
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Madrid, Spain
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Seville, Spain
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Malmö, Sweden
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Mölndal, Sweden
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Stockholm, Sweden
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Uppsala, Sweden
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London, Greater London, United Kingdom
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Isleworth, Middlesex, United Kingdom
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Glasgow, Renfrewshire, United Kingdom
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Bath, United Kingdom
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Swindon, United Kingdom
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Los Angeles, California, 90024, United States
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New Haven, Connecticut, 06510, United States
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Boca Raton, Florida, 33486, United States
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Leesburg, Florida, 34749, United States
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Miami, Florida, 33137, United States
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Tampa, Florida, 33613, United States
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Atlanta, Georgia, 30308, United States
Facility #2

Boston, Massachusetts, 02118, United States
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New York, New York, 10021, United States
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Rochester, New York, 14623, United States
Facility #2

Oklahoma City, Oklahoma, 73116, United States
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Portland, Oregon, 97210, United States
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Dallas, Texas, United States
Facility #2

San Antonio, Texas, 78229, United States
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London, Ontario, Canada
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Berlin, Germany
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Roma, Italy
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Seoul, South Korea
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Madrid, Spain
Facility #2

London, United Kingdom
Facility #3

Los Angeles, California, 90024, United States
Facility #3

Miami, Florida, 33145, United States
Facility #3

Tampa, Florida, 33609, United States
Facility #3

San Antonio, Texas, 78229, United States
Facility #3

Berlin, Germany
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Roma, Italy
Facility #3

Seoul, South Korea
Facility #4

Seoul, South Korea

Conditions

Explore the condition pages connected to this study.

ALZHEIMER S DISEASE