New pill shows promise for rare Brain-Related obesity
NCT ID NCT06046443
First seen Feb 24, 2026 · Last updated May 13, 2026 · Updated 8 times
Summary
This study tested an experimental drug called LB54640 in 28 people aged 12 and older with hypothalamic obesity, a condition where brain injury causes rapid weight gain. Participants took either the drug or a placebo daily for 14 weeks, then could continue on the drug for up to a year. The goal was to see if the drug safely reduces weight and hunger.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Birmingham Women's and Children's NHS Foundation Trust
Birmingham, B15 2TG, United Kingdom
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Columbia University
New York, New York, 10027, United States
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Great Ormond Street Hospital for Children
London, WC1N 3JH, United Kingdom
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Lynn Health Science Institute
Oklahoma City, Oklahoma, 73112, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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The University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, 27514, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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University of Cambridge
Cambridge, CB2 1TN, United Kingdom
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University of Iowa Children's Hospital
Iowa City, Iowa, 52242, United States
Conditions
Explore the condition pages connected to this study.