Engineered immune cells take on late-stage lymphoma in new trial
NCT ID NCT07254754
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial is testing a single infusion of axicabtagene ciloleucel, a CAR T-cell therapy, in 45 adults whose diffuse large B-cell lymphoma has returned more than a year after previous treatment. The main goal is to see how many patients have no signs of cancer on a PET/CT scan three months after treatment. Participants will be followed for up to five years to monitor long-term effects and outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
axicabtagene ciloleucel (a CAR T-cell therapy made from the patient's own immune cells)
What this could lead to
If successful, this could offer a treatment option for people whose lymphoma returns more than a year after initial therapy, potentially leading to long-term remission.
What could go wrong
This is a small, early-phase (Phase 2) trial with only 45 participants, so results may not apply to everyone. CAR T-cell therapy can cause serious side effects like cytokine release syndrome and neurological problems.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clínica Universidad de Navarra
RECRUITINGPamplona, Navarre, 31008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Complejo Hospitalario Universitario A Coruña
RECRUITINGA Coruña, A Coruña, 15008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Complejo Hospitalario Universitario de Gran Canaria Dr. Negrín
RECRUITINGLas Palmas de Gran Canaria, Las Palmas, 35019, Spain
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clinic i Provincial de Barcelona
RECRUITINGBarcelona, Catalonia, 08036, Spain
Contact
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Clínico Universitario de Valencia
RECRUITINGValencia, Valencia, 46010, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital General Universitario Gregorio Marañón
RECRUITINGMadrid, Madrid, 28007, Spain
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Contact
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Hospital General Universitario Morales Meseguer
RECRUITINGMurcia, Murcia, 30008, Spain
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitari Vall d'Hebron
RECRUITINGBarcelona, Catalonia, 08035, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
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Contact
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Hospital Universitario Donostia
RECRUITINGSan Sebastián, Gipuzkoa, Spain
Contact
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Hospital Universitario Marqués de Valdecilla
RECRUITINGSantander, Cantabria, 39008, Spain
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Hospital Universitario Son Espases
RECRUITINGPalma de Mallorca, Balearic Islands, 7120, Spain
Contact
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario Virgen del Rocío
RECRUITINGSeville, Sevilla, 41013, Spain
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Contact
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Hospital Universitario de Salamanca
RECRUITINGSalamanca, Castille and León, 37007, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Català d'oncologia de L'Hospitalet
RECRUITINGL'Hospitalet de Llobregat, Catalonia, 08908, Spain
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••