Massive west african trial takes on deadly lassa fever with new drug cocktail

NCT ID NCT06212336

Recruiting now Disease control Sponsor: Irrua Specialist Teaching Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large clinical trial in West Africa is testing several drugs—including favipiravir, ribavirin, dexamethasone, and a new drug called ARN-75039—to find a better treatment for Lassa fever, a viral disease that kills thousands each year. The study will enroll about 1,755 hospitalized patients and measure whether these drugs reduce death and organ failure compared to standard care. The goal is to find a safer and more effective option than the current treatment, ribavirin, which has serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Favipiravir, Ribavirin, Dexamethasone, ARN-75039
What this could lead to: If successful, this trial could identify a safer and more effective treatment for Lassa fever, potentially saving thousands of lives in West Africa.
What could go wrong: This is an early-to-mid stage trial, and the drugs may not prove more effective than current care. Ribavirin has known toxicity, and new drugs like ARN-75039 are still being tested for safety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Communicable Diseases, Emerging Lassa fever viral hemorrhagic fever

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LASSA FEVER

Contacts and locations

Locations

Abubakar Tafawa Balewa University Teaching Hospital
NOT_YET_RECRUITING

Bauchi, Nigeria
Federal Medical Center Owo
RECRUITING

Owo, Ondo State, Nigeria
Irrua Specialist Teaching Hospital
RECRUITING

Irrua, Edo, Nigeria
Phebe Hospital
NOT_YET_RECRUITING

Suacoco, Bong County, Liberia

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