Voice box transplants offer new hope for those who lost their voice

NCT ID NCT03269396

First seen Nov 01, 2025 · Last updated Apr 09, 2026 · Updated 21 times

Summary

This study aims to test the safety and effectiveness of transplanting a donor voice box (larynx) into patients with severe, permanent throat damage who have no other good treatment options. It will follow 10 patients to see if the transplant survives, and to measure improvements in their voice, swallowing, and breathing. Because it is a transplant, patients will need to take lifelong anti-rejection medications to prevent their body from attacking the new organ.

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Contacts and locations

Locations

  • Mayo Clinic in Arizona

    Phoenix, Arizona, 85054, United States

Conditions

Explore the condition pages connected to this study.