Targeted drug shows promise against multiple cancers with shared genetic flaw

NCT ID NCT02576431

Summary

This study tested how well the drug larotrectinib works against advanced solid tumors that have a specific genetic change called an NTRK fusion. It involved 215 adults with various cancer types who had already tried standard treatments. Larotrectinib is designed to block the abnormal protein created by the NTRK gene fusion, aiming to shrink tumors and control the cancer.

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Contacts and locations

Locations

  • 1st Moscow State Medical University n.a. I.M.Sechenov

    Moscow, 119991, Russia

  • A.O.R.N. San Giuseppe Moscati

    Avellino, Campania, 83100, Italy

  • A.O.U. di Bologna Policlinico S.Orsola Malpighi

    Bologna, Emilia-Romagna, 40138, Italy

  • A.S.U. Friuli Centrale - A. Regionale Coordinamento Salute

    Udine, Friuli Venezia Giulia, 33038, Italy

  • APHP-Hopital la Pitie Salpetriere-Departement oncologie

    Paris, 75013, France

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha, 751019, India

  • Arkhangelsk Clinical Oncology Dispensary

    Arkhangelsk, 163045, Russia

  • Asan Medical Center-Ophthalmology

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Avera Cancer Institute - Sioux Falls

    Sioux Falls, South Dakota, 57105, United States

  • Beijing Cancer Hospital - Oncology Department

    Beijing, Beijing Municipality, 100142, China

  • Cenantron Centro Avançado de Tratamento Oncológico, Ltda.

    Belo Horizonte, Minas Gerais, 30130-090, Brazil

  • Centre Antoine Lacassagne - Departement Oncologie

    Nice, 06100, France

  • Centro Estudios Médicos e Invest. Clínicas "Dr. N. Quirno"

    Buenos Aires, Ciudad Auton. de Buenos Aires, TBC, Argentina

  • Centro Integral Oncológico Clara Campal

    Madrid, 28050, Spain

  • Centro Medico Austral

    TBC, Ciudad Auton. de Buenos Aires, C1019ABS, Argentina

  • Centro Médico San Roque

    San Miguel de Tucumán, Tucumán Province, T4000HXU, Argentina

  • Charité Comprehensive Cancer Center (CCCC)

    Berlin, 12203, Germany

  • Ciutat Sanitaria i Universitaria de la Vall d'Hebron

    Barcelona, 08035, Spain

  • Cleveland Clinic - Neurology

    Cleveland, Ohio, 44195, United States

  • Clinical Diagnostical Center

    Nizhny Novgorod, 603006, Russia

  • Dana-Farber Cancer Institute - Oncology Department

    Boston, Massachusetts, 02215, United States

  • Erciyes Universitesi Tip Fakultesi

    Kayseri, 38039, Turkey (Türkiye)

  • Fakultní Nemocnice Olomouc

    Olomouc, 77900, Czechia

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Fred Hutch Cancer Center - Sloan Clinic 1

    Seattle, Washington, 98109, United States

  • Fundacao Pio XII - Hospital de Cancer de Barretos

    Barretos/SP, São Paulo, 14784-400, Brazil

  • Fundación Cenit para la Investigación en Neurociencias

    CABA, Ciudad Auton. de Buenos Aires, C1125 ABD, Argentina

  • Fundación Oftalmológica de Santander Carlos Ardila Lule

    Floridablanca, Santander Department, 681004, Colombia

  • Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital

    Ankara, 6800, Turkey (Türkiye)

  • Hokkaido University Hospital

    Sapporo, Hokkaido, 060-8648, Japan

  • Hopital Jean Minjoz

    Besançon, 25030, France

  • Hopital Saint Antoine APHP - Departement Oncologie

    Paris, 75012, France

  • Hosp. Araujo Jorge da Associação de Combate ao Câncer

    Goiânia, Goiás, 74605-070, Brazil

  • Hospital Alemán

    Buenos Aires, Ciudad Auton. de Buenos Aires, C11118AAT, Argentina

  • Hospital General Universitario Gregorio Maranon | Oncologia

    Madrid, 28007, Spain

  • Hospital Sirio Libanes

    São Paulo, 01409-000, Brazil

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Hôpital de la Milétrie

    Poitiers, 86021, France

  • IBCC - Instituto Brasileiro de Controle do Cancer

    São Paulo, São Paulo, 03102-002, Brazil

  • ICANS - Institut de Cancerologie de Strasbourg Europe - service oncologie medicale

    Strasbourg, 67200, France

  • INCA - Hospital do Cancer III

    Rio de Janeiro, 20560-120, Brazil

  • IPO Porto

    Porto, 4200-072, Portugal

  • IRCCS Istituti Fisioterapici Ospitalieri - IFO

    Rome, Lazio, 144, Italy

  • Inova Schar Cancer Institute

    Fairfax, Virginia, 22031, United States

  • Institut Bergonie - Unicancer Nouvelle Aquitaine - Service Oncologie medicale

    Bordeaux, 33000, France

  • Institut Catala D'oncologia - Oncologia

    Barcelona, L Hospitalet de Llobregat, 8907, Spain

  • Institut Jules Bordet/Jules Bordet Instituut

    Brussels, 1070, Belgium

  • Institut de Cancerologie Ouest - Saint-Herblain

    Saint-Herblain, 44800, France

  • Instituto Nacional de Cancerología INC Colombia

    Bogota, Cundinamarca, 111511, Colombia

  • Instituto Nacional do Câncer - INCA - HC II

    Rio de Janeiro, 20081-250, Brazil

  • Instituto do Cancer do Estado de Sao Paulo

    São Paulo, São Paulo, 01246-000, Brazil

  • Istanbul Universitesi Cerrahpasa-Cerrahpasa Tip Fakultesi

    Istanbul, 34098, Turkey (Türkiye)

  • Istanbul Universitesi Istanbul Tip Fakultesi

    Istanbul, 34093, Turkey (Türkiye)

  • Istituto Europeo di Oncologia s.r.l

    Milan, Lombardy, 20141, Italy

  • Istituto Oncologico Veneto

    Padua, Veneto, 35128, Italy

  • Izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma

    Izmir, 35360, Turkey (Türkiye)

  • Jawaharlal Institute Of Postgraduate Medical Education and R

    Gorimedu, Puducherry, 605006, India

  • Karolinska Universitetssjukhuset Solna - Tema Cancer

    Stockholm, 171 76, Sweden

  • Macquarie University Hospital

    Sydney, New South Wales, 2109, Australia

  • Mass General Cancer Center

    Boston, Massachusetts, 02114-2696, United States

  • Memorial Cancer Institute at West

    Pembroke Pines, Florida, 33026, United States

  • Memorial Sloan Kettering Cancer Center New York - Main Campus

    New York, New York, 10065, United States

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • Narodny onkologicky ustav

    Bratislava, 833 10, Slovakia

  • National Cancer Center Hospital East

    Kashiwa, Chiba, 277-8577, Japan

  • National Cancer Center Singapore - Oncology Department

    Singapore, 168583, Singapore

  • Oncoclínicas Rio de Janeiro S.A

    Rio de Janeiro, 22250-905, Brazil

  • Oncomédica S.A.

    Montería, Departamento de Córdoba, 230002, Colombia

  • Onkologicky Ustav Svatej Alzbety, s.r.o.

    Bratislava, 812 50, Slovakia

  • Real e Benemérita Associação Portuguesa de Beneficência

    São Paulo, São Paulo, 01323-001, Brazil

  • Republican Clinical Oncology Dispensary Kazan

    Kazan', 420029, Russia

  • Rigshospitalet - Kræftbehandling

    Copenhagen OE, 2100, Denmark

  • Royal Darwin Hospital

    Tiwi, Northern Territory, 810, Australia

  • Russian Oncological Scientific Center n.a. N.N. Blokhin RAMS

    Moscow, 115478, Russia

  • Samsung Medical Center - Oncology Department

    Seoul, 06351, South Korea

  • Seoul National University Hospital

    Seoul, Seoul Teugbyeolsi, 3080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Seoul Teugbyeolsi, 03722, South Korea

  • Sichuan University West China Hospital

    Chengdu, Sichuan, MISSING, China

  • Sidney Kimmel Cancer Center - Jefferson Health

    Philadelphia, Pennsylvania, 19107, United States

  • St John of God Healthcare

    Subiaco, Western Australia, 6008, Australia

  • St Vincents University Hospital

    Dublin, TBC, Ireland

  • St. Petersburg Clinical Onc. Cent. of Spec. Types of Care

    Saint Petersburg, 197758, Russia

  • Stanford Cancer Center Palo Alto

    Palo Alto, California, 94304, United States

  • Sun Yat-sen University Cancer Center

    Guangzhou, Guangdong, 510000, China

  • TC Saglik Bakanligi Goztepe ProfDr Suleyman Yalcin Sehir Has

    Istanbul, 34722, Turkey (Türkiye)

  • The Cancer Institute Hospital of JFCR

    Koto-ku, Tokyo, 135-8550, Japan

  • The University of Chicago Medical Center - Hyde Park - Hematology & Oncology

    Chicago, Illinois, 60637, United States

  • The University of Texas MD Anderson Cancer Center - Texas Medical Center

    Houston, Texas, 77030, United States

  • Tom Baker Cancer Centre

    Calgary, Alberta, T2N 4N2, Canada

  • Trakya Univ. Tip Fak.

    Edirne, 22030, Turkey (Türkiye)

  • Tri-Service General Hospital

    Taipei, 114, Taiwan

  • UCLA Health Santa Monica Cancer Care

    Santa Monica, California, 90404, United States

  • UNC Hospitals - UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27514, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Wake Forest Baptist Health

    Winston-Salem, North Carolina, 27157, United States

  • West Virginia University

    Morgantown, West Virginia, 26505, United States

  • Zhongshan Hospital, Fudan University - Oncology Department

    Shanghai, 200032, China

Conditions

Explore the condition pages connected to this study.