Could a probiotic in the bladder ease catheter troubles?

NCT ID NCT04323735

Recruiting now Symptom relief Sponsor: Medstar Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a probiotic (Lactobacillus Rhamnosus GG) placed directly into the bladder can reduce urinary symptoms in people with neurogenic bladder who use an indwelling catheter. Researchers will also look at changes in urine inflammation, bacteria, and the overall urine ecosystem. The goal is to find the best dose for a future larger trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lactobacillus Rhamnosus GG (a probiotic)
What this could lead to: If it works, this could point toward a simple, non-antibiotic way to reduce urinary symptoms and infections in people with neurogenic bladder who use catheters.
What could go wrong: This is an early Phase 2 trial with only 182 participants, so results may not apply to everyone. The probiotic may not improve symptoms or could cause irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Urinary Bladder, Neurogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROGENIC BLADDER

Contacts and locations

Locations

MedStar National Rehabilitation Hospital
RECRUITING

Washington D.C., District of Columbia, 20010, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.