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CAR t therapy takes on myasthenia gravis in major new trial

NCT ID NCT06193889

Recruiting now Disease control Sponsor: Kyverna Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This study tests a new treatment called KYV-101, made from a patient's own immune cells, against standard immunosuppressive drugs for generalized myasthenia gravis. About 66 adults who have not responded to at least two prior therapies will be randomly assigned to receive either KYV-101 or continue standard care. The goal is to see if KYV-101 can better improve daily living and muscle strength while managing side effects.

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Conditions

The condition(s) this trial relates to.

autoimmune disease myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENERALIZED MYASTHENIA GRAVIS MYASTHENIA GRAVIS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Cambridge University Hospital, Addenbrooke's Hospital

    RECRUITING

    Cambridge, United Kingdom

  • Charite- Universitätsklinikum Berlin

    RECRUITING

    Berlin, Germany

  • Friedrich-Schiller-Universität Jena

    RECRUITING

    Jena, Germany

  • Hospital Israelita Albert Einstein

    RECRUITING

    São Paulo, Brazil

  • Houston Methodist Hospital

    RECRUITING

    Houston, Texas, 77030, United States

  • Indiana University Health

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Intermountain Medical Center

    RECRUITING

    Murray, Utah, 84107, United States

  • King's College Hospital

    RECRUITING

    London, United Kingdom

  • King's Faisal Specialist Hospital and Research Center

    RECRUITING

    Riyadh, Kindom of Saudi Arabia, Saudi Arabia

  • Medizinische Hochscule Hannover

    RECRUITING

    Hanover, Germany

  • Oregon Health & Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Ronald Reagan UCLA Medical Center

    RECRUITING

    Los Angeles, California, 90095, United States

  • Stanford University Medical Center

    RECRUITING

    Palo Alto, California, 94305, United States

  • Technical University Munich, Klinikum Rechts der Isar

    RECRUITING

    Munich, Germany

  • Thomas Jefferson University Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • University of California, Irvine

    RECRUITING

    Orange, California, 92868, United States

  • University of Miami

    RECRUITING

    Miami, Florida, 33149, United States

  • University of Missouri

    RECRUITING

    Columbia, Missouri, 65212, United States

  • Universitätsklinik Magdeburg

    RECRUITING

    Magdeburg, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    RECRUITING

    Hamburg, Germany

  • Universitätsklinikum der Ruhr-Universität Bochum

    RECRUITING

    Bochum, Germany

  • Westmead Institute for Medical Research

    RECRUITING

    Westmead, Australia

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