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Stem cell eye drops aim to heal stubborn corneal defects

NCT ID NCT05727878

Terminated Disease control Sponsor: Combangio, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an eye drop called KPI-012, made from substances released by stem cells, to see if it could heal persistent corneal epithelial defects (PCED) — wounds on the eye's surface that won't close. The trial enrolled 103 people with PCED from various causes. Participants received either the active drop or a placebo. The main goal was complete healing of the wound. However, the study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

KPI-012 (a solution of proteins and other factors from stem cells)

What this could lead to

If successful, KPI-012 could become a new treatment option for stubborn corneal wounds that don't heal on their own.

What could go wrong

The trial was terminated early, so we have limited data. It's a small Phase 2 study, and the treatment may not prove effective or safe in larger trials.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERSISTENT CORNEAL EPITHELIAL DEFECT

Contacts and locations

Locations

  • Principal Investigator

    Dothan, Alabama, 36301, United States

  • Principal Investigator

    Irvine, California, 92897, United States

  • Principal Investigator

    La Jolla, California, 92037, United States

  • Principal Investigator

    Loma Linda, California, 92354, United States

  • Principal Investigator

    Los Angeles, California, 90013, United States

  • Principal Investigator

    Los Angeles, California, 90095, United States

  • Principal Investigator

    Pasadena, California, 91107, United States

  • Principal Investigator

    Rancho Cordova, California, 95670, United States

  • Principal Investigator

    Aurora, Colorado, 80045, United States

  • Principal Investigator

    Fort Collins, Colorado, 80528, United States

  • Principal Investigator

    Littleton, Colorado, 80120, United States

  • Principal Investigator

    Miami, Florida, 33136, United States

  • Principal Investigator

    Miami, Florida, 33143, United States

  • Principal Investigator

    Orange City, Florida, 32763, United States

  • Principal Investigator

    Atlanta, Georgia, 30339, United States

  • Principal Investigator

    Carmel, Indiana, 46290, United States

  • Principal Investigator

    Indianapolis, Indiana, 46260, United States

  • Principal Investigator

    Louisville, Kentucky, 40206, United States

  • Principal Investigator

    Boston, Massachusetts, 02111, United States

  • Principal Investigator

    Boston, Massachusetts, 02114, United States

  • Principal Investigator

    Chesterfield, Missouri, 63017, United States

  • Principal Investigator

    Kansas City, Missouri, 64111, United States

  • Principal Investigator

    Kansas City, Missouri, 64133, United States

  • Principal Investigator

    St Louis, Missouri, 63131, United States

  • Principal Investigator

    Palisades Park, New Jersey, 07650, United States

  • Principal Investigator

    New York, New York, 10036, United States

  • Principal Investigator

    Rockville Centre, New York, 11570, United States

  • Principal Investigator

    Garner, North Carolina, 27529, United States

  • Principal Investigator

    Powell, Ohio, 43065, United States

  • Principal Investigator

    Philadelphia, Pennsylvania, 19107, United States

  • Principal Investigator

    Pittsburgh, Pennsylvania, 15219, United States

  • Principal Investigator

    Rapid City, South Dakota, 57701, United States

  • Principal Investigator

    Memphis, Tennessee, 38119, United States

  • Principal Investigator

    Nashville, Tennessee, 37215, United States

  • Principal Investigator

    Austin, Texas, 78712, United States

  • Principal Investigator

    Austin, Texas, 78731, United States

  • Principal Investigator

    Houston, Texas, 77030, United States

  • Principal Investigator

    San Antonio, Texas, 78212, United States

  • Principal Investigator

    Norfolk, Virginia, 23502, United States

  • Principal Investigator

    Seattle, Washington, 98119, United States

  • Principal Investigator

    Morgantown, West Virginia, 25606, United States

  • Principal Investigator

    Kenosha, Wisconsin, 53142, United States

  • Principal Investigator

    Caba, Buenos Aires, C1428ARF, Argentina

  • Principal Investigator

    Rosario, Santa Fe Province, S2000, Argentina

  • Principal Investigator

    San Juan, 00921, Puerto Rico

  • Principal investigator

    Durham, North Carolina, 27710, United States

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