Amniotic injection shows promise for knee arthritis relief

NCT ID NCT04636229

Completed Symptom relief Sponsor: Organogenesis Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 27 times

Summary

This study tested whether an injection made from amniotic tissue (ASA) can reduce pain and improve function in people with knee osteoarthritis. 516 adults with knee OA received either ASA or a placebo injection. The main goal was to measure pain changes over 6 months using a standard questionnaire.

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Contacts and locations

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Locations

AARDS Research, Inc.

Aventura, Florida, 33180, United States
AMR Mobile

Mobile, Alabama, 36608, United States
Actca, A Member of the Allliance Inc.

Los Angeles, California, 90036, United States
Affinity Health

Oak Brook, Illinois, 60523, United States
Affinity Health

Nashville, Tennessee, 37203, United States
Alabama Clinical Therapeutics

Birmingham, Alabama, 35235, United States
Arizona Arthritis & Rheumatology Research

Glendale, Arizona, 85306, United States
Arizona Arthritis & Rheumatology Research

Tucson, Arizona, 85704, United States
Cedar Health Research, LLC

Burleson, Texas, 76028, United States
Central Research Associates

Birmingham, Alabama, 35205, United States
Chicago Clinical Research Institute Inc

Chicago, Illinois, 60607, United States
Coastal Carolina Research Center

North Charleston, South Carolina, 29406, United States
Fiel Family & Sports Medicine/ CCT Research

Tempe, Arizona, 85283, United States
Gulfcoast Research Institute

Sarasota, Florida, 34232, United States
Horizon Clinical Research Center

La Mesa, California, 91942, United States
Hospital for Special Surgery

New York, New York, 10021, United States
Injury Care Research

Boise, Idaho, 83713, United States
Klein & Associates, MD, PA

Hagerstown, Maryland, 21740, United States
Lehigh Center for Clinical Research

Allentown, Pennsylvania, 18104, United States
Lenox Hill Hospital (Northwell Health)

New York, New York, 10075, United States
M3 Emerging Medical Research, LLC

Durham, North Carolina, 27704, United States
M3 Emerging Medical Research, LLC

Raleigh, North Carolina, 27612, United States
Methodist Physicians Clinic/ CCT Researc

Fremont, Nebraska, 68025, United States
Moore Orthopedics and Sports Medicine

Morehead City, North Carolina, 28557, United States
NYU Langone Health

New York, New York, 10016, United States
PCPMG Clinical Research Unit, LLC

Greenville, South Carolina, 29501, United States
Physician Research Collaboration

Lincoln, Nebraska, 68516, United States
Pinnacle Trials, Inc.

Stockbridge, Georgia, 30281, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Sinai Hospital of Baltimore

Baltimore, Maryland, 21215, United States
Spectrum Medical, Inc

Danville, Virginia, 24541, United States
Stanford Medicine

Redwood City, California, 94063, United States
Tri West Research Associates

El Cajon, California, 92020, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University Orthopedic Center

State College, Pennsylvania, 16801, United States
University Orthopedics Center

Altoona, Pennsylvania, 16602, United States
University of California at Davis

Sacramento, California, 95186, United States
University of California at Los Angeles

Los Angeles, California, 90095, United States

Conditions

Explore the condition pages connected to this study.

KNEE OSTEOARTHRITIS