New knee shot shows promise for osteoarthritis sufferers

NCT ID NCT03727022

First seen Jan 12, 2026 · Last updated May 15, 2026 · Updated 19 times

Summary

This study tested an experimental drug called SM04690, given as two injections into the knee about six months apart, in 101 people with moderate to severe knee osteoarthritis. The main goal was to check safety and measure changes in bone density in the treated knee compared to a placebo. Participants were followed for one year, with an option to continue for another year.

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Contacts and locations

Locations

  • Research Site

    Phoenix, Arizona, 85018, United States

  • Research Site

    Phoenix, Arizona, 85053, United States

  • Research Site

    Canoga Park, California, 91303, United States

  • Research Site

    Carmichael, California, 95628, United States

  • Research Site

    La Mesa, California, 91941, United States

  • Research Site

    Edgewater, Florida, 32132, United States

  • Research Site

    Miami, Florida, 33143, United States

  • Research Site

    Woodstock, Georgia, 30189, United States

  • Research Site

    Kansas City, Missouri, 64114, United States

  • Research Site

    Albuquerque, New Mexico, 87102, United States

  • Research Site

    Cincinnati, Ohio, 45246, United States

  • Research Site

    Charleston, South Carolina, 29406, United States

  • Research Site

    San Angelo, Texas, 76904, United States

Conditions

Explore the condition pages connected to this study.