Knee osteoarthritis drug trial halted midway

NCT ID NCT04864392

Terminated Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Apr 24, 2026 · Last updated May 12, 2026 · Updated 2 times

Summary

This study tested an experimental drug called LNA043, given as a shot into the knee, to see if it could slow down cartilage loss and reduce pain in people with knee osteoarthritis. The trial planned to enroll 576 adults aged 40 to 75 with knee osteoarthritis. The study was terminated early, so results are limited.

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Contacts and locations

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Locations

AMR Knoxville

Knoxville, Tennessee, 37920, United States
Annapolis Rheumatology LLC

Fairfax, Virginia, 22033, United States
Artemis Institute Clinical Research

Riverside, California, 92503, United States
Arthemis Clinical Research

San Diego, California, 92103, United States
Center For Pharmaceutical Research

Kansas City, Missouri, 64114, United States
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Chicago Clinical Research Inst

Chicago, Illinois, 60607, United States
Clinical Research of West Florida Inc

Tampa, Florida, 33603, United States
Clinical Trials Research

Lincoln, California, 95648, United States
Conquest Research

Winter Park, Florida, 32789, United States
Drug Trials America

Hartsdale, New York, 10530, United States
Elite Clinical Studies

Phoenix, Arizona, 85018, United States
Long Beach Clinical Trials

Long Beach, California, 90806, United States
Metroplex Clinical Research

Dallas, Texas, 75231, United States
Northern California Research

Sacramento, California, 95821, United States
Novartis Investigative Site

Caba, C1428AZF, Argentina
Novartis Investigative Site

Córdoba, X5000EOC, Argentina
Novartis Investigative Site

San Miguel de Tucumán, 4000, Argentina
Novartis Investigative Site

Broadmeadow, New South Wales, 2292, Australia
Novartis Investigative Site

Maroochydore, Queensland, 4558, Australia
Novartis Investigative Site

Woodville South, South Australia, 5011, Australia
Novartis Investigative Site

Hobart, Tasmania, 7000, Australia
Novartis Investigative Site

Malvern East, Victoria, 3145, Australia
Novartis Investigative Site

Christchurch, 8011, Australia
Novartis Investigative Site

St Leonards, 2065, Australia
Novartis Investigative Site

Waikanae Beach, 5036, Australia
Novartis Investigative Site

Québec, Quebec, G1V 3M7, Canada
Novartis Investigative Site

Trois-Rivières, Quebec, G9A 3Y2, Canada
Novartis Investigative Site

Beijing, Beijing Municipality, 100044, China
Novartis Investigative Site

Bengbu, 233004, China
Novartis Investigative Site

Brno, Czech Republic, 66250, Czechia
Novartis Investigative Site

Pardubice, Czech Republic, 530 02, Czechia
Novartis Investigative Site

Brno-Zidonice, CZE, 61500, Czechia
Novartis Investigative Site

Brno, 638 00, Czechia
Novartis Investigative Site

Uherské Hradiště, 686 01, Czechia
Novartis Investigative Site

Aarhus N, 8200, Denmark
Novartis Investigative Site

Gandrup, 9362, Denmark
Novartis Investigative Site

Vejle, 7100, Denmark
Novartis Investigative Site

Tallinn, 10128, Estonia
Novartis Investigative Site

Tartu, 50708, Estonia
Novartis Investigative Site

Vadodara, Gujarat, 390022, India
Novartis Investigative Site

Belagavi, Karnataka, 590010, India
Novartis Investigative Site

Lucknow, Uttar Pradesh, 226003, India
Novartis Investigative Site

Pune, 411019, India
Novartis Investigative Site

Shinagawa, Tokyo, 140 0014, Japan
Novartis Investigative Site

Shinjuku Ku, Tokyo, 160-0008, Japan
Novartis Investigative Site

Suginami, Tokyo, 166-0002, Japan
Novartis Investigative Site

Chuoh-ku, 104-0031, Japan
Novartis Investigative Site

Osaka, 543-0027, Japan
Novartis Investigative Site

Guadalajara, Jalisco, 44650, Mexico
Novartis Investigative Site

Culiacán, Sinaloa, 80000, Mexico
Novartis Investigative Site

Ciudad de, CP 06700, Mexico
Novartis Investigative Site

Kielce, 25-017, Poland
Novartis Investigative Site

Krakow, 31-501, Poland
Novartis Investigative Site

Poznan, 60-446, Poland
Novartis Investigative Site

Warsaw, 02-677, Poland
Novartis Investigative Site

Santiago, A Coruna, 15705, Spain
Novartis Investigative Site

Sabadell, Barcelona, 08208, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08003, Spain
Novartis Investigative Site

A Coruña, 15006, Spain
Novartis Investigative Site

Madrid, 28046, Spain
Novartis Investigative Site

Seville, 41010, Spain
Novartis Investigative Site

Changhua, 50006, Taiwan
Novartis Investigative Site

Tainan, 704302, Taiwan
Novartis Investigative Site

Glasgow, Scotland, G51 4TF, United Kingdom
Novartis Investigative Site

Barnet, EN5 3DJ, United Kingdom
Novartis Investigative Site

Norwich, NR4 7UY, United Kingdom
Pioneer Research Solutions

Sugar Land, Texas, 77479, United States
Sensible Healthcare

Ocoee, Florida, 34761, United States
Sharps Hospital Grossmont

La Mesa, California, 91942, United States
Stamford Therapeutics Consortium LLC

Stamford, Connecticut, 06905, United States
Tandem clinical research

Marrero, Louisiana, 70072, United States
The Center for Rheumatology and Bone Research

Wheaton, Maryland, 20902, United States
Tucson Orthopedic Institute PC

Tucson, Arizona, 85712, United States
Virginia Ispine Physicians PC

Richmond, Virginia, 23238, United States

Conditions

Explore the condition pages connected to this study.

OSTEOARTHRITIS