One shot to ease knee pain? new study tests lorecivivint

NCT ID NCT04385303

Completed Symptom relief Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Feb 04, 2026 · Last updated May 16, 2026 · Updated 12 times

Summary

This study tested a single injection of lorecivivint in the knee joint of 496 adults with moderate to severe knee osteoarthritis. The goal was to see if it reduces pain and improves function compared to a placebo over 28 weeks. Participants reported their pain levels weekly using a 0-10 scale.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35205, United States
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Birmingham, Alabama, 35215, United States
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Mobile, Alabama, 36608, United States
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Phoenix, Arizona, 85018, United States
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Phoenix, Arizona, 85053, United States
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Tucson, Arizona, 85712, United States
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Little Rock, Arkansas, 72205, United States
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Anaheim, California, 92805, United States
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Beverly Hills, California, 90211, United States
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Canoga Park, California, 91303, United States
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Garden Grove, California, 92840, United States
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La Mesa, California, 91942, United States
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Norco, California, 92860, United States
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Pomona, California, 91767, United States
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San Diego, California, 92103, United States
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Santa Monica, California, 90404, United States
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Thousand Oaks, California, 91360, United States
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Westminster, California, 92683, United States
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Boulder, Colorado, 80301, United States
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Hamden, Connecticut, 06517, United States
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Edgewater, Florida, 32132, United States
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Gulf Breeze, Florida, 32561, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33173, United States
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Miami Lakes, Florida, 33014, United States
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Sunrise, Florida, 33351, United States
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Sweetwater, Florida, 33172, United States
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West Palm Beach, Florida, 33409, United States
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Winter Haven, Florida, 33880, United States
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Marietta, Georgia, 30060, United States
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Newnan, Georgia, 30265, United States
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Woodstock, Georgia, 30189, United States
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Boise, Idaho, 83713, United States
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Chicago, Illinois, 60607, United States
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Gurnee, Illinois, 60031, United States
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Oak Brook, Illinois, 60523, United States
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Evansville, Indiana, 47714, United States
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Greenwood, Indiana, 46143, United States
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Valparaiso, Indiana, 46383, United States
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New Orleans, Louisiana, 70124, United States
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Wheaton, Maryland, 20902, United States
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Boston, Massachusetts, 02111, United States
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Troy, Michigan, 48085, United States
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Hazelwood, Missouri, 63042, United States
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Kansas City, Missouri, 64114, United States
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Omaha, Nebraska, 68114, United States
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Las Vegas, Nevada, 89119, United States
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Reno, Nevada, 89519, United States
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Freehold, New Jersey, 07728, United States
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Albuquerque, New Mexico, 87102, United States
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Hartsdale, New York, 10530, United States
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Rochester, New York, 14642, United States
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Greensboro, North Carolina, 27408, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Cincinnati, Ohio, 45224, United States
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Edmond, Oklahoma, 73013, United States
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Duncansville, Pennsylvania, 16635, United States
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Charleston, South Carolina, 29406, United States
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Fort Mill, South Carolina, 29707, United States
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Mt. Pleasant, South Carolina, 29464, United States
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Rapid City, South Dakota, 57702, United States
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Bellaire, Texas, 77401, United States
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Carrollton, Texas, 75007, United States
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Dallas, Texas, 75231, United States
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Houston, Texas, 77029, United States
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Plano, Texas, 75075, United States
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Draper, Utah, 84020, United States
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Ogden, Utah, 84405, United States
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Salt Lake City, Utah, 84107, United States
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Charlottesville, Virginia, 22911, United States
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Richmond, Virginia, 23219, United States
Research Site 1

Winter Park, Florida, 32789, United States
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St Louis, Missouri, 63141, United States
Research Site 2

St Louis, Missouri, 63141, United States
Reserach Site

Clearwater, Florida, 33761, United States

Conditions

Explore the condition pages connected to this study.

KNEE OSTEOARTHRITIS