One-Shot knee injection tested as potential Game-Changer for arthritis pain

NCT ID NCT04385303

Completed Disease control Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether a single injection of an experimental drug called lorecivivint could reduce pain and improve function in people with moderate-to-severe knee osteoarthritis. Nearly 500 adults received either the drug or a placebo injection into their most painful knee and were followed for 28 weeks. Researchers measured changes in participants' self-reported pain levels, physical function, and overall assessment of their knee condition.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35205, United States
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Birmingham, Alabama, 35215, United States
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Mobile, Alabama, 36608, United States
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Phoenix, Arizona, 85018, United States
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Phoenix, Arizona, 85053, United States
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Tucson, Arizona, 85712, United States
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Little Rock, Arkansas, 72205, United States
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Anaheim, California, 92805, United States
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Beverly Hills, California, 90211, United States
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Canoga Park, California, 91303, United States
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Garden Grove, California, 92840, United States
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La Mesa, California, 91942, United States
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Norco, California, 92860, United States
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Pomona, California, 91767, United States
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San Diego, California, 92103, United States
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Santa Monica, California, 90404, United States
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Thousand Oaks, California, 91360, United States
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Westminster, California, 92683, United States
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Boulder, Colorado, 80301, United States
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Hamden, Connecticut, 06517, United States
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Edgewater, Florida, 32132, United States
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Gulf Breeze, Florida, 32561, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33173, United States
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Miami Lakes, Florida, 33014, United States
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Sunrise, Florida, 33351, United States
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Sweetwater, Florida, 33172, United States
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West Palm Beach, Florida, 33409, United States
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Winter Haven, Florida, 33880, United States
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Marietta, Georgia, 30060, United States
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Newnan, Georgia, 30265, United States
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Woodstock, Georgia, 30189, United States
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Boise, Idaho, 83713, United States
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Chicago, Illinois, 60607, United States
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Gurnee, Illinois, 60031, United States
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Oak Brook, Illinois, 60523, United States
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Evansville, Indiana, 47714, United States
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Greenwood, Indiana, 46143, United States
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Valparaiso, Indiana, 46383, United States
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New Orleans, Louisiana, 70124, United States
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Wheaton, Maryland, 20902, United States
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Boston, Massachusetts, 02111, United States
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Troy, Michigan, 48085, United States
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Hazelwood, Missouri, 63042, United States
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Kansas City, Missouri, 64114, United States
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Omaha, Nebraska, 68114, United States
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Las Vegas, Nevada, 89119, United States
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Reno, Nevada, 89519, United States
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Freehold, New Jersey, 07728, United States
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Albuquerque, New Mexico, 87102, United States
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Hartsdale, New York, 10530, United States
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Rochester, New York, 14642, United States
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Greensboro, North Carolina, 27408, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Cincinnati, Ohio, 45224, United States
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Edmond, Oklahoma, 73013, United States
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Duncansville, Pennsylvania, 16635, United States
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Charleston, South Carolina, 29406, United States
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Fort Mill, South Carolina, 29707, United States
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Mt. Pleasant, South Carolina, 29464, United States
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Rapid City, South Dakota, 57702, United States
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Bellaire, Texas, 77401, United States
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Carrollton, Texas, 75007, United States
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Dallas, Texas, 75231, United States
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Houston, Texas, 77029, United States
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Plano, Texas, 75075, United States
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Draper, Utah, 84020, United States
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Ogden, Utah, 84405, United States
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Salt Lake City, Utah, 84107, United States
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Charlottesville, Virginia, 22911, United States
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Richmond, Virginia, 23219, United States
Research Site 1

Winter Park, Florida, 32789, United States
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St Louis, Missouri, 63141, United States
Research Site 2

St Louis, Missouri, 63141, United States
Reserach Site

Clearwater, Florida, 33761, United States

Conditions

Explore the condition pages connected to this study.

KNEE OSTEOARTHRITIS