One-Shot knee injection tested for lasting arthritis relief

NCT ID NCT03928184

Completed Disease control Sponsor: Biosplice Therapeutics, Inc. Source: ClinicalTrials.gov ↗

Summary

This completed Phase 3 trial tested whether a single injection of an experimental drug, lorecivivint, could safely reduce pain and improve function in adults with moderate-to-severe knee osteoarthritis. Over 500 participants received either the drug or a placebo injection into their most painful knee. Researchers measured changes in pain, physical function, and joint space over 56 weeks to see if the treatment provided lasting benefit.

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Contacts and locations

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Locations

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Birmingham, Alabama, 35205, United States
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Birmingham, Alabama, 35215, United States
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Birmingham, Alabama, 35216, United States
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Peoria, Arizona, 85381, United States
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Phoenix, Arizona, 85037, United States
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Tucson, Arizona, 85712, United States
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Little Rock, Arkansas, 72205, United States
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Anaheim, California, 92805, United States
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Garden Grove, California, 92840, United States
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Norco, California, 92860, United States
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Pomona, California, 91767, United States
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San Diego, California, 92103, United States
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San Marcos, California, 92078, United States
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Spring Valley, California, 91978, United States
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Westminster, California, 92683, United States
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Boulder, Colorado, 80301, United States
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Colorado Springs, Colorado, 80918, United States
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Denver, Colorado, 80209, United States
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Waterbury, Connecticut, 06708, United States
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Clearwater, Florida, 33761, United States
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Coral Gables, Florida, 33134, United States
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Hialeah, Florida, 33016, United States
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Miami, Florida, 33143, United States
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Miami Lakes, Florida, 33014, United States
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Orlando, Florida, 32806, United States
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Oviedo, Florida, 32765, United States
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Port Orange, Florida, 32127, United States
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Sunrise, Florida, 33351, United States
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West Palm Beach, Florida, 33409, United States
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Winter Haven, Florida, 33880, United States
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Marietta, Georgia, 30060, United States
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Newnan, Georgia, 30265, United States
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Stockbridge, Georgia, 30281, United States
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Woodstock, Georgia, 30189, United States
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Boise, Idaho, 83713, United States
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Meridian, Idaho, 83642, United States
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Bloomington, Illinois, 61704, United States
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Gurnee, Illinois, 60031, United States
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Oak Brook, Illinois, 60523, United States
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Rockford, Illinois, 61114, United States
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Anderson, Indiana, 46011, United States
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Evansville, Indiana, 47714, United States
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Valparaiso, Indiana, 46383, United States
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Kansas City, Kansas, 66160, United States
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Wichita, Kansas, 67205, United States
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Monroe, Louisiana, 71203, United States
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New Orleans, Louisiana, 70124, United States
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Wheaton, Maryland, 20902, United States
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Boston, Massachusetts, 02111, United States
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Bay City, Michigan, 48706, United States
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Troy, Michigan, 48085, United States
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Hazelwood, Missouri, 63042, United States
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St Louis, Missouri, 63141, United States
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La Vista, Nebraska, 68128, United States
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Lincoln, Nebraska, 68516, United States
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Omaha, Nebraska, 68114, United States
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Albuquerque, New Mexico, 87108, United States
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Great Neck, New York, 11021, United States
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Hartsdale, New York, 10530, United States
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New York, New York, 10016, United States
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Rochester, New York, 14609, United States
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Williamsville, New York, 14221, United States
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Charlotte, North Carolina, 28209, United States
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Leland, North Carolina, 28451, United States
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Salisbury, North Carolina, 28144, United States
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Winston-Salem, North Carolina, 27103, United States
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Fargo, North Dakota, 58104, United States
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Cincinnati, Ohio, 45219, United States
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Cincinnati, Ohio, 45224, United States
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Cincinnati, Ohio, 45242, United States
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Columbus, Ohio, 43235, United States
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Oklahoma City, Oklahoma, 73103, United States
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Oklahoma City, Oklahoma, 73112, United States
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Duncansville, Pennsylvania, 16635, United States
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Fort Mill, South Carolina, 29707, United States
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Greenville, South Carolina, 29607, United States
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Greer, South Carolina, 29651, United States
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Mt. Pleasant, South Carolina, 29464, United States
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Rapid City, South Dakota, 57702, United States
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Austin, Texas, 78745, United States
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Bedford, Texas, 76021, United States
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Carrollton, Texas, 75007, United States
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Dallas, Texas, 75231, United States
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Edinburg, Texas, 78539, United States
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Houston, Texas, 77029, United States
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Houston, Texas, 77055, United States
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Plano, Texas, 75075, United States
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San Antonio, Texas, 78215, United States
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San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78258, United States
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Draper, Utah, 84020, United States
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Murray, Utah, 84123, United States
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Salt Lake City, Utah, 84107, United States
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Charlottesville, Virginia, 22911, United States
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Richmond, Virginia, 23219, United States
Research Site #1

Winter Park, Florida, 32789, United States
Research Site #2

Winter Park, Florida, 32789, United States
Research Site 1

New York, New York, 10021, United States
Research Site 2

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

KNEE OSTEOARTHRITIS