Two-Drug combo may help kids with rare lung condition breathe easier
NCT ID NCT04039464
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 34 times
Summary
This study tested whether giving children with pulmonary hypertension two oral medications (sildenafil and bosentan) right from the start works better than giving just one (sildenafil alone). The goal was to see if the two-drug approach improved their physical activity level and slowed disease worsening over 12 months. The trial enrolled 28 children who had not yet received long-term treatment for this condition.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Columbia University Medical Center
New York, New York, 10032, United States
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Johns Hopkins All Children's Hospital
St. Petersburg, Florida, 33701, United States
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Johns Hopkins Medical Institutions
Baltimore, Maryland, 21287, United States
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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New York Medical College
Valhalla, New York, 10595, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Conditions
Explore the condition pages connected to this study.