New Two-Drug combo aims to halt kidney failure in major trial

NCT ID NCT06087835

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether adding a new drug called zibotentan to an existing kidney drug (dapagliflozin) can better protect kidney function in people with chronic kidney disease who have high levels of protein in their urine. The goal is to see if the combination slows the decline of kidney function more than dapagliflozin alone and reduces the risk of serious kidney problems. About 1,835 adults who are already on standard kidney-protecting medication are participating.

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Locations

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Huntsville, Alabama, 35805, United States
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Sun City West, Arizona, 85375, United States
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Bakersfield, California, 93309, United States
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Huntington Park, California, 90255, United States
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Los Alamitos, California, 90720, United States
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Los Angeles, California, 90010, United States
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Northridge, California, 91324, United States
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Oxnard, California, 93036, United States
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San Carlos, California, 94070, United States
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San Dimas, California, 91773, United States
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Tarzana, California, 91356, United States
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Victorville, California, 92392, United States
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Arvada, Colorado, 80002, United States
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Denver, Colorado, 80230, United States
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Boynton Beach, Florida, 33435, United States
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Hialeah, Florida, 33016, United States
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Hollywood, Florida, 33024, United States
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Jacksonville, Florida, 32204, United States
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Jensen Beach, Florida, 34957, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33165, United States
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Orlando, Florida, 32806, United States
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Fayetteville, Georgia, 30214, United States
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Champaign, Illinois, 61822, United States
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Chicago, Illinois, 60616, United States
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Hinsdale, Illinois, 60521, United States
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Island Lake, Illinois, 60042, United States
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Skokie, Illinois, 60077, United States
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Bowling Green, Kentucky, 42101, United States
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Shreveport, Louisiana, 71101, United States
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Silver Spring, Maryland, 20901, United States
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Flint, Michigan, 48504, United States
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Flint, Michigan, 48532, United States
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Troy, Michigan, 48098, United States
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City of Saint Peters, Missouri, 63376, United States
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Albany, New York, 12205, United States
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Middletown, New York, 10940, United States
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Orchard Park, New York, 14127, United States
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Greenville, North Carolina, 27834, United States
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Jacksonville, North Carolina, 28546, United States
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Kinston, North Carolina, 28504, United States
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New Bern, North Carolina, 28562, United States
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Statesville, North Carolina, 28625, United States
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Wilmington, North Carolina, 28401, United States
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Wilmington, North Carolina, 28412, United States
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Winston-Salem, North Carolina, 27103, United States
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Maumee, Ohio, 43537, United States
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Pottstown, Pennsylvania, 19464, United States
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East Providence, Rhode Island, 02915, United States
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Kingsport, Tennessee, 37660, United States
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Arlington, Texas, 76015, United States
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Austin, Texas, 78726, United States
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Houston, Texas, 77004, United States
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Houston, Texas, 77099, United States
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Pearland, Texas, 77584, United States
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San Antonio, Texas, 78204, United States
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San Antonio, Texas, 78207, United States
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San Antonio, Texas, 78212, United States
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Sugar Land, Texas, 77478, United States
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Salt Lake City, Utah, 84115, United States
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Alexandria, Virginia, 22311, United States
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Newport News, Virginia, 23606, United States
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Mukilteo, Washington, 98275, United States
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Spokane, Washington, 99202, United States
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Ciudad de Buenos Aires, 1280, Argentina
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Ciudad de Buenos Aires, C1425AGC, Argentina
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Mar del Plata, 7600, Argentina
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Mar del Plata, B7600, Argentina
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Santa Fe, S3000, Argentina
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Gosford, 2250, Australia
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Meadowbrook, 4131, Australia
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Perth, 6000, Australia
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Reservoir, 3021, Australia
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Reservoir, 3073, Australia
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Southport, 4222, Australia
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Feldkirch, 6800, Austria
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Vienna, 1130, Austria
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Belém, 66073-005, Brazil
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Botucatu, 18618-687, Brazil
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Joinville, 89227-680, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01228-200, Brazil
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São Paulo, 04012-909, Brazil
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São Paulo, 04038-031, Brazil
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Dobrich, 9300, Bulgaria
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Pleven, 5800, Bulgaria
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Plovdiv, 4000, Bulgaria
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Plovdiv, 4001, Bulgaria
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Sofia, 1680, Bulgaria
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Stara Zagora, 6000, Bulgaria
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London, Ontario, N6A 5A5, Canada
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Waterloo, Ontario, N2T 0C1, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Baotou, 014010, China
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Beijing, 100029, China
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Beijing, 102218, China
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Changsha, 410013, China
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Chengdu, 610000, China
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Chengdu, 610072, China
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Chongqing, 400010, China
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Deyang, 618000, China
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Foshan, 528000, China
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Guangzhou, 510120, China
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Guangzhou, 510515, China
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Hangzhou, 310014, China
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Hengyang, 421001, China
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Linhai, 317000, China
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Nanjing, 210009, China
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Nanjing, 210011, China
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Nanning, 530022, China
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Ningbo, 315010, China
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Pingxiang, 337055, China
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Shanghai, 200240, China
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Shantou, 515041, China
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Shenzhen, 518039, China
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Shenzhen, 518053, China
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Wenzhou, 325000, China
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Wuhan, 430010, China
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Wuxi, 214000, China
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Xi'an, 710077, China
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Xiamen, 361101, China
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Yantai, 264000, China
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Yibin, 610500, China
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Yinchuan, 750004, China
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Zhuzhou, 412007, China
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Zigong, 643000, China
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Aalborg, 9100, Denmark
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Aarhus, 8200, Denmark
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Herlev, 2730, Denmark
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Herning, 7400, Denmark
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Roskilde, 4000, Denmark
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La Tronche, 38700, France
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Mulhouse, 68100, France
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Nice, 06000, France
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Nîmes, 30000, France
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Rouen, 76031, France
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Saint-Priest-en-Jarez, 42270, France
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Strasbourg, 67090, France
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Tours, 37000, France
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Aachen, 52074, Germany
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Bad Oeynhausen, 32545, Germany
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Berlin, 10117, Germany
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Dresden, 01279, Germany
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Hanover, 30625, Germany
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Mainz, 55131, Germany
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München, 80336, Germany
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Bangalore, 560060, India
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Belagavi, 590010, India
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Delhi, 110029, India
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Nadiād, 387001, India
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New Delhi, 110017, India
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Ashkelon, 78278, Israel
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Haifa, 3109601, Israel
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Jerusalem, 9372212, Israel
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Kfar Saba, 44281, Israel
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Nahariya, 22100, Israel
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Petah Tikva, 49372, Israel
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Ramat Gan, 52621, Israel
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Rehovot, 76100, Israel
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Bergamo, 24127, Italy
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Bologna, 40138, Italy
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Foggia, 71100, Italy
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Genoa, 16132, Italy
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Napoli, 80138, Italy
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Pisa, 56124, Italy
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Roma, 161, Italy
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Torino, 10126, Italy
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Chūōku, 103-0027, Japan
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Fujisawa-shi, 251-0041, Japan
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Fukui-shi, 910-8526, Japan
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Fukuoka, 810-0001, Japan
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Fukuoka, 810-8563, Japan
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Fukuoka, 819-0168, Japan
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Hashima-gun, 501-6061, Japan
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Kamakura-shi, 247-0056, Japan
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Kasuga-shi, 816-0864, Japan
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Kawaguchi-shi, 332-0012, Japan
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Kitakyushu-shi, 802-8555, Japan
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Kitakyusyu-shi, 806-8501, Japan
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Kofu, 400-8506, Japan
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Kurume-shi, 830-0011, Japan
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Kurume-shi, 830-8543, Japan
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Kusatsu-shi, 525-8585, Japan
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Kyoto, 607-8062, Japan
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Matsumoto-shi, 390-8510, Japan
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Meguro-ku, 153-0061, Japan
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Minatoku, 108-0073, Japan
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Minokamo Shi, 505-8510, Japan
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Nishinomiya-Shi, 662-0918, Japan
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Nishinomiya-shi, 662-0971, Japan
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Okawa-shi, 831-0016, Japan
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Osaka, 550-0006, Japan
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Osaka, 559-0012, Japan
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Oyama-shi, 323-0022, Japan
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Sakushu, 385-8558, Japan
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Sapporo, 003-0026, Japan
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Sapporo, 062-0931, Japan
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Sendai, 980-8574, Japan
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Soka-shi, 340-0015, Japan
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Takamatsu, 760-0076, Japan
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Takasago-shi, 676-0812, Japan
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Tondabayashi-shi, 584-0082, Japan
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Toride-shi, 302-0022, Japan
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Urayasu, 279-0001, Japan
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Utsunomiya, 320-8580, Japan
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Alor Star, 5460, Malaysia
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Ipoh, 30990, Malaysia
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Kota Kinabalu, 88200, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Seremban, 70300, Malaysia
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Seri Manjung, 32040, Malaysia
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Mazatlán, 82110, Mexico
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Amersfoort, 3813 TZ, Netherlands
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Breda, 4818 CK, Netherlands
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Dordrecht, 3318 AT, Netherlands
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Bodø, 8073, Norway
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Lørenskog, 1478, Norway
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Oslo, 0450, Norway
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Stavanger, 4011, Norway
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Tromsø, 9019, Norway
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Chrzanów, 32-500, Poland
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Krakow, 31-156, Poland
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Krakow, 31-501, Poland
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Lodz, 92-213, Poland
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Poznan, 60-354, Poland
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Radom, 26-600, Poland
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Rzeszów, 35-055, Poland
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Szczecin, 70-111, Poland
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Warsaw, 03-291, Poland
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Lučenec, 984 01, Slovakia
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Prešov, 080 01, Slovakia
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Púchov, 020 01, Slovakia
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Rožňava, 048 01, Slovakia
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Trebišov, 07501, Slovakia
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Benoni, 1501, South Africa
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Cape Town, 7925, South Africa
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Chatsworth, 4092, South Africa
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Durban, 4450, South Africa
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Lenasia, 1827, South Africa
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Midrand, 1685, South Africa
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Parow, 7505, South Africa
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Ansan-si, 15355, South Korea
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Busan, 49241, South Korea
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Cheonan-si, 31151, South Korea
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Daegu, 41944, South Korea
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Goyang-si, 10380, South Korea
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Seoul, 06591, South Korea
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Seoul, 120-752, South Korea
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Seoul, 156-707, South Korea
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Girona, 17007, Spain
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L'Hospitalet de Llobregat, 08907, Spain
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Lugo, 27004, Spain
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Madrid, 28041, Spain
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Majadahonda, 28222, Spain
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Seville, 41071, Spain
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Valencia, 46010, Spain
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Gothenburg, 413 46, Sweden
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Linköping, 581 85, Sweden
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Rättvik, 79530, Sweden
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Stockholm, 141 86, Sweden
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Uppsala, 751 85, Sweden
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Kaohsiung City, 807, Taiwan
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Kaohsiung City, 833, Taiwan
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New Taipei City, 220, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 710, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taipei, 11490, Taiwan
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Taoyuan District, 333, Taiwan
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Bangkok, 10330, Thailand
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Bangkok, 10700, Thailand
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Chaingmai, 50200, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Ratchathewi, 10400, Thailand
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Adapazarı, 54100, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Dinar, 03400, Turkey (Türkiye)
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Kahramanmaraş, 46040, Turkey (Türkiye)
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Kayseri, 38039, Turkey (Türkiye)
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Kocaeli, 41380, Turkey (Türkiye)
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Cardiff, CF14 4XW, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Glasgow, G51 4TF, United Kingdom
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London, EC1A 2BE, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE5 9RJ, United Kingdom
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York, YO21 8HE, United Kingdom
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Haiphong, 180000, Vietnam
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Hanoi, 10000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Ho Chi Minh City, 70000, Vietnam
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Ho Chi Minh City, Vietnam

Conditions

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CHRONIC KIDNEY DISEASE WITH HIGH PROTEINURIA