New drug combo may help High-Risk kidney cancer patients avoid full kidney removal

NCT ID NCT07389629

Recruiting now Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Feb 05, 2026 · Last updated Jun 08, 2026 · Updated 19 times

Summary

This study tests whether giving a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus lenvatinib before surgery can shrink kidney tumors enough to allow a partial nephrectomy (removing only the tumor, not the whole kidney) in patients with localized renal cell carcinoma who are at high surgical risk. About 25 adults with clear cell renal cancer and a high R.E.N.A.L. score will receive the treatment before surgery. The main goal is to see if the tumor complexity score decreases, making surgery safer and kidney-sparing possible.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, 0755, China

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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CLEAR CELL RENAL CELL CARCINOMA IPAROMLIMAB AND TUVONRALIMAB NEOADJUVANT THERAPY