New drug combo JSKN033 tested for Hard-to-Treat cancers
NCT ID NCT06226766
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial tested a new drug called JSKN033 in 11 people with advanced or spreading solid tumors that have a protein called HER2. The drug is a combination of two medicines given as a shot under the skin. The study aimed to check safety, side effects, and the right dose, but it was stopped early. It is too soon to know if this approach works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
JSKN033 (a combination of two drugs: JSKN003 and envafolimab)
What this could lead to
If it works, this could point toward a new treatment option for people with advanced solid tumors that have a specific marker (HER2).
What could go wrong
This trial was terminated early and only enrolled 11 people, so results are very limited. It is a first-in-human study, meaning safety and effectiveness are not yet established.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Scientia Clinical Research
Randwick, New South Wales, 2031, Australia