New combo therapy aims to slow prostate cancer spread

NCT ID NCT06991556

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, JSB462, combined with standard therapy (abiraterone) in 150 men whose prostate cancer has spread but still responds to hormone treatment. The goal is to see if the combination lowers PSA levels more effectively and delays cancer growth. Participants will receive either the new combo or another standard treatment, and researchers will monitor safety and side effects.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC HORMONE-SENSITIVE PROSTATE CANCER

Contacts and locations

Locations

Advanced Urology Ins Daytona Beach
RECRUITING

Daytona Beach, Florida, 32114, United States
American Oncology Partners PA Center for Cancer and Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States
Associated Med Professionals of NY
RECRUITING

Syracuse, New York, 13210, United States
Associated Urological Specialists
RECRUITING

Chicago Ridge, Illinois, 60415, United States
Carolina Urologic Research Center
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
Emory University School of Medicine-Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutch Cancer Research
RECRUITING

Seattle, Washington, 98109, United States
Mass General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Michigan Institute of Urology
RECRUITING

West Bloomfield, Michigan, 48322, United States
MidLantic Urology
RECRUITING

Bala-Cynwyd, Pennsylvania, 19004, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Novartis Investigative Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Novartis Investigative Site
RECRUITING

Clayton, Victoria, 3168, Australia
Novartis Investigative Site
RECRUITING

Fortaleza, Ceará, 60140-025, Brazil
Novartis Investigative Site
RECRUITING

São Paulo, São Paulo, 01221-020, Brazil
Novartis Investigative Site
RECRUITING

Vancouver, British Columbia, V5Z 1M9, Canada
Novartis Investigative Site
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Novartis Investigative Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Novartis Investigative Site
RECRUITING

Beijing, Chaoyang, 100021, China
Novartis Investigative Site
RECRUITING

Beijing, 100034, China
Novartis Investigative Site
RECRUITING

Brno, 656 53, Czechia
Novartis Investigative Site
RECRUITING

Olomouc, 779 00, Czechia
Novartis Investigative Site
RECRUITING

Prague, 150 06, Czechia
Novartis Investigative Site
RECRUITING

Nice, Alpes Maritimes, 06189, France
Novartis Investigative Site
RECRUITING

Marseille, 13273, France
Novartis Investigative Site
RECRUITING

Quint-Fonsegrives, 31130, France
Novartis Investigative Site
RECRUITING

Suresnes, 92150, France
Novartis Investigative Site
RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Novartis Investigative Site
RECRUITING

Hamburg, 20246, Germany
Novartis Investigative Site
RECRUITING

Lübeck, 23538, Germany
Novartis Investigative Site
RECRUITING

Nürtingen, 72622, Germany
Novartis Investigative Site
RECRUITING

Asti, AT, 14100, Italy
Novartis Investigative Site
RECRUITING

Padova, PD, 35128, Italy
Novartis Investigative Site
RECRUITING

Trento, TN, 38122, Italy
Novartis Investigative Site
RECRUITING

Orbassano, TO, 10043, Italy
Novartis Investigative Site
RECRUITING

Verona, VR, 37134, Italy
Novartis Investigative Site
RECRUITING

Zwolle, Overijssel, 8025 AB, Netherlands
Novartis Investigative Site
RECRUITING

Dordrecht, South Holland, 3318 AT, Netherlands
Novartis Investigative Site
RECRUITING

Hoofddorp, 2134 TM, Netherlands
Novartis Investigative Site
RECRUITING

Schiedam, 3118 JH, Netherlands
Novartis Investigative Site
RECRUITING

Kielce, 25-640, Poland
Novartis Investigative Site
RECRUITING

Olsztyn, 10-288, Poland
Novartis Investigative Site
RECRUITING

Oświęcim, 32-600, Poland
Novartis Investigative Site
RECRUITING

Skorzewo, 60-185, Poland
Novartis Investigative Site
RECRUITING

Singapore, 119074, Singapore
Novartis Investigative Site
RECRUITING

Singapore, 169608, Singapore
Novartis Investigative Site
RECRUITING

Singapore, S308433, Singapore
Novartis Investigative Site
RECRUITING

Seoul, 03080, South Korea
Novartis Investigative Site
RECRUITING

Seoul, 06351, South Korea
Novartis Investigative Site
RECRUITING

Santander, Cantabria, 39008, Spain
Novartis Investigative Site
RECRUITING

Badajoz, Extremadura, 06080, Spain
Novartis Investigative Site
RECRUITING

Lugo, Galicia, 27003, Spain
Novartis Investigative Site
RECRUITING

Pamplona, Navarre, 31008, Spain
Novartis Investigative Site
RECRUITING

Barcelona, 08036, Spain
Novartis Investigative Site
RECRUITING

Córdoba, 14004, Spain
Novartis Investigative Site
RECRUITING

Kaohsiung City, 83301, Taiwan
Novartis Investigative Site
RECRUITING

Tainan, 704302, Taiwan
Perlmutter Cancer Centre
RECRUITING

New York, New York, 10016, United States
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Saint Johns Cancer Institute
RECRUITING

Santa Monica, California, 90404, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
University of California San Diego - Moores Cancer Center
RECRUITING

La Jolla, California, 92093-0658, United States
Urology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States
XCancer Omaha LLC
RECRUITING

Omaha, Nebraska, 68130, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06520, United States

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