New hope for stomach cancer: experimental drug JS107 enters final trial phase

NCT ID NCT07284134

Recruiting now Disease control Sponsor: Shanghai Junshi Bioscience Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing an experimental drug called JS107 against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has gotten worse after at least one prior therapy. The study will enroll about 560 participants who have a specific marker (CLDN18.2) on their cancer cells. The goal is to see if JS107 can help people live longer or delay cancer growth compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JS107 (an experimental drug targeting CLDN18.2)
What this could lead to: If successful, JS107 could offer a new treatment option for people with advanced gastric cancer that has not responded to prior therapy.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The drug may not improve survival or could cause side effects. The study is still recruiting, so outcomes are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED GASTRIC OR GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

Locations

Affiliated Hospital Of Jiangnan University
NOT_YET_RECRUITING

Wuxi, Jiangsu, 214122, China
Affiliated Hospital of North China University of Technology
NOT_YET_RECRUITING

Tangshan, Hebei, 063000, China
AnHui Provincial Cancer Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230031, China
Anyang Tumor Hospital
NOT_YET_RECRUITING

Anyang, Henan, 455000, China
Baotou Tumor Hospital
NOT_YET_RECRUITING

Baotou, Inner Mongolia, 014030, China
Beijing Friendship Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100050, China
Binzhou Medical University Hospital
NOT_YET_RECRUITING

Binzhou, Shandong, 256603, China
Cancer Hospital Affiliated to Guangxi Medical University
NOT_YET_RECRUITING

Nanning, Guangxi, 530000, China
Cancer Hospital Chinese Academy of Medical Sciences Langfang Campus
NOT_YET_RECRUITING

Langfang, Hebei, 065001, China
Cancer Hospital of Shantou University Medical College
RECRUITING

Shantou, Guangdong, 515041, China
Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350014, China
First hospital of Shanxi medical university
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030001, China
Gansu Provincial Cancer Hospital
NOT_YET_RECRUITING

Lanzhou, Gansu, 730050, China
Gansu wuwei tumor hospital
NOT_YET_RECRUITING

Wuwei, Gansu, 733000, China
General Hospital of Ningxia Medical university
NOT_YET_RECRUITING

Yinchuan, Ningxia, 750004, China
Harbin Medical University Cancer Hospital
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450008, China
Hubei Cancer Hospital
NOT_YET_RECRUITING

Wuhan, Hubei, 430079, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410013, China
Jiangsu Province Hospital
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210029, China
Jiangxi Cancer Hospital (Jiangxi Second People's Hospital)
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330029, China
Liaoning Cancer Hospital&Institute
NOT_YET_RECRUITING

Shenyang, Liaoning, 110042, China
Linfen central hospital
NOT_YET_RECRUITING

Linfen, Shanxi, 041000, China
Linyi Cancer Hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276000, China
Linyi People's Hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276034, China
Meizhou People's Hospital（Huangtang Hospital）
NOT_YET_RECRUITING

Meizhou, Guangdong, 514031, China
Nanfang hospital
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
Nanyang First People's Hospital National Third Class A Hospltal
NOT_YET_RECRUITING

Nanyang, Henan, 473010, China
Northern Jiangsu People's Hospital
NOT_YET_RECRUITING

Yangzhou, Jiangsu, 225001, China
Peking University First Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100034, China
People's Hospital of Guangxi Zhuang Autonomous Region
NOT_YET_RECRUITING

Nanning, Guangxi, 530000, China
Puyang People's Hospital
NOT_YET_RECRUITING

Puyang, Henan, 457100, China
Sanmenxia Central Hospital
NOT_YET_RECRUITING

Sanmenxia, Henan, 472099, China
Shandong First Medical University Affiliated Tumor Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
Shandong Provincial Hospital
NOT_YET_RECRUITING

Ji'nan, Shandong, 250021, China
Shanghai Gobroad Cancer Hospital China Pharmaceutical University
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200123, China
Shanxi Bethune Hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030032, China
Shanxi cancer hospital
NOT_YET_RECRUITING

Taiyuan, Shanxi, 030013, China
Shengjing Hospital 0f China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110004, China
Suining Central Hospital
NOT_YET_RECRUITING

Suining, Sichuan, 629000, China
Sun Yat-sen University Cancer Center
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510000, China
The Affiliated Hospital of Qingdao University
NOT_YET_RECRUITING

Qingdao, Shandong, 266075, China
The First Affiliated Hospital of Henan University of Science & Technology
NOT_YET_RECRUITING

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Nanchang University
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330209, China
The First Affiliated Hospital of Wenzhou Medical University
NOT_YET_RECRUITING

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xi'an jiao tong University
NOT_YET_RECRUITING

Xi’an, Shanxi, 710061, China
The First Affiliated Hospital of Zhengzhouuniversity
NOT_YET_RECRUITING

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital, Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310003, China
The First Hospital of Lanzhou University
NOT_YET_RECRUITING

Lanzhou, Gansu, 730000, China
The Fourth Hospital of Hebei Medical University
NOT_YET_RECRUITING

Shijiazhuang, Hebei, 050011, China
The Second Affiliated Hospital Zhejiang University School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310009, China
The Third Bethune Hospital Of Jilin University
NOT_YET_RECRUITING

Changchun, Jilin, 130033, China
The Third People's Hospital of Datong
NOT_YET_RECRUITING

Datong, Shanxi, 037046, China
The second people's hospital of Yibin
NOT_YET_RECRUITING

Yibin, Sichuan, 644002, China
The sixth affiliated hospital sun yat-sen university
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510655, China
Tongji Hospital, Tongji Medical College, Huazhong University
NOT_YET_RECRUITING

Wuhan, Hubei, 430000, China
Union Hospital Affiliated to Fujian Medical University
NOT_YET_RECRUITING

Fuzhou, Fujian, 365110, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430040, China
Weifang People's Hospital
NOT_YET_RECRUITING

Weifang, Shandong, 261000, China
West China Hospital, Sichuan University
NOT_YET_RECRUITING

Chengdu, Sichuan, 610041, China
Xiangya Hospital of Central South University
NOT_YET_RECRUITING

Changsha, Hunan, 410008, China
Xiangyang Cancer Hospital
NOT_YET_RECRUITING

Xiangyang, Hubei, 441199, China
Xinjiang Medical University Affiliated Tumor Hospital
NOT_YET_RECRUITING

Ürümqi, Xinjiang, 830000, China
Xuzhou Central Hospital
NOT_YET_RECRUITING

Xuzhou, Jiangsu, 221111, China
Yichang Central People's Hospital
NOT_YET_RECRUITING

Yichang, Hubei, 443003, China
Yunnan Cancer Hospital
NOT_YET_RECRUITING

Kunming, Yunnan, 650118, China
Zhejiang Provincial People'S Hospital People'S Hospital of Hangzhou Medicalcollege
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310014, China
Zhoukou Central Hospital
RECRUITING

Zhoukou, Henan, 466099, China

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